Everyday Wellness with Cynthia Thurlow ™

BONUS: Dr. Felice Gersh: Estrogen, Immunity & Menopause Mysteries

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Apr 21, 2025

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INSIGHT

Estrogen Types and Receptors

Estrogen is not a single hormone but a family including estradiol, estrone, and estriol, each with distinct effects.
Different organs have varying estrogen receptors, influencing the hormone's diverse functions in the body.

INSIGHT

Estrogen and Mast Cell Activation

Mast cells are key immune first responders abundant at external interfaces like skin and mucous membranes.
Fluctuating estradiol levels in menopause dysregulate mast cell activation, causing histamine reactions like hives.

INSIGHT

Gut Microbiome and Estrogen Recycling

The gut microbiome, through the estrobolome, critically recycles estrogen and modulates immune responses.
Dysbiosis and leaky gut in menopausal women lower the threshold for inflammation, creating a perfect storm for immune dysregulation.

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Prepare to be enlightened by an engaging discussion with a true powerhouse in women's health!

I have the pleasure of being joined once again by the esteemed Dr. Felice Gersh, a renowned physician with a cutting-edge career in obstetrics, gynecology, and integrative medicine.

In today’s episode, Dr. Gersh and I explore the intricate interplay between estrogen and immune function, delving into the impact of ovarian aging, menopause, bone health, mental cognition, sleep, and mood. We traverse the vast landscape of the gut microbiome and vascular system, unraveling the secrets of different estrogen types and receptors while addressing the crucial role of inflammation.

With a keen focus on hormone replacement therapy, Dr. Gersh also shares her invaluable insights on the critical window for intervention and her exceptional approach to caring for women in perimenopause and menopause.

Dr. Felice Gersh is an invaluable resource on women’s health! Tune in for an enriching discussion that will leave you eagerly anticipating more episodes with this esteemed physician!

IN THIS EPISODE YOU WILL LEARN:

Dr. Gersh discusses hormone supplementation and menopause.
The role of estrogen in the immune system
The systemic effects of estrogens
How to turn off the switch to inflammation
The connection between estrogen and the gut microbiome
The role of estradiol in the body
Having a healthy gut will translate into a healthy liver and vice versa.
The magic of phytoestrogens
The perfect storm for creating breast cancer
Is there a magic window of time for menopause?
Estrogen receptors and the risk of blood clotting

Connect with Cynthia Thurlow

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Check out Cynthia’s website

Connect with Dr. Felice Gersh

On her website: Integrative Medical Group of Irvine

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All of Dr. Gersh’s books are available on Amazon

Previous Episodes Mentioned

Ep. 221 Part 1- An Integrative Approach to PCOS and Menstrual Irregularities with Dr. Felice Gersh

Ep. 237 Perimenopause and Menopause: What You Didn’t Know with Dr. Felice Gersh