How Silent Inflammation Accelerates Aging with Dr. David Furman

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Dec 21, 2022

In this engaging discussion, Dr. David Furman, an immunology expert and director at the Buck Institute, sheds light on the complex world of inflammation as it relates to aging. He breaks down how silent inflammation can undermine health and resilience against diseases like autoimmunity and cancer. They delve into groundbreaking research on immune system biomarkers and their connection to longevity. Listeners are introduced to innovative blood analysis methods and promising therapeutic interventions to combat the effects of aging.

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INSIGHT

Human Immunology Research

Human immunology research often relies on animal models, but findings don't always translate to humans.
Directly studying humans reveals vast individual variation in immune systems, necessitating a systems biology approach.

INSIGHT

Sterile Inflammation and Aging

Aging involves increased sterile inflammation, distinct from acute inflammation from infections.
Sterile inflammation, driven by non-infectious triggers, reduces resilience to autoimmunity, cancer, and chronic diseases.

INSIGHT

Inflammation: The Driver of Aging

Multiple factors like pollution, diet, and stress contribute to age-related inflammation.
This systemic chronic inflammation drives all recognized hallmarks of aging.

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This episode is brought to you by Rupa Health, BiOptimizers, and InsideTracker.

If you’re interested in health, you’ve heard the term inflammation quite a bit. But did you know there are different kinds of inflammation? Some of them are more alarming than others. Acute inflammation happens when you cut your finger and it gets red and a little swollen. This is helpful inflammation and usually resolves in about a week. But the inflammation that naturally happens as we age, called sterile-inflammation, sets us up for less resiliency against things like autoimmunity, cancer, and other forms of chronic disease.

Today, I’m excited to dive deep into the topic of inflammation and its role in aging with Dr. David Furman. Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans.

This episode is brought to you by Rupa Health, BiOptimizers, and InsideTracker.

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Here are more details from our interview (audio version / Apple Subscriber version):

The origins of Dr. Furman’s unique thinking about the immune system and aging (7:21 / 3:58)
Types of inflammation (11:13 / 8:02)
How systemic chronic inflammation drives all of the hallmarks of aging (13:32 / 10:30)
Causes of inflammation (18:24 / 13:46)
The immunome and the 1000 Immunomes Project (26:31 / 21:14)
How inflammatory age can be used to predict disease (33:13 / 27:12)
Predicting frailty in individuals years before they become frail (35:54 / 30:37)
Newly discovered biomarkers that can be used for early detection of age-related disease (38:54 / 32:02)
How the iAge test will be used in the future (47:58 / 43:42)
Learnings from centenarians (59:24 / 54:12)

Learn more about the 1000 Immunomes Project.