Renee Belz & Lauren Sambataro

Dr. John Lieurance on Melatonin: the "Miracle Molecule" and Methylene Blue For Stress Resilience, Brain Inflammation, Immune Support, Circadian Rhythm

Aug 28, 2023
Dr. John Lieurance discusses the powerful biohacks of high-dose melatonin and methylene blue supplementation. He explores the uses of melatonin beyond sleep regulation, its benefits for chronic health conditions, and optimal dosing. The conversation also covers the role of neuroinflammation, the significance of the 'blue spot' in the brain, and the importance of grounding and sun gazing for overall health and wellness.
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INSIGHT

Melatonin As A Stress-Resilience Molecule

  • Melatonin is a primary stress-resilience molecule that supports cellular energy and adaptation to stress.
  • Raising melatonin can extend life and increase resilience across many organ systems.
INSIGHT

Gut Makes Most Melatonin

  • Most melatonin in the body is produced outside the pineal, notably in the gut at much higher levels.
  • Gut-derived melatonin regulates microbiome swarming and suppresses pathogenic bacteria to prevent dysbiosis.
ADVICE

Time Melatonin With Evening Light-Dark Cycle

  • Take melatonin earlier in the evening rather than immediately before bed to align with circadian timing.
  • Use suppository forms for longer coverage and liposomal for quicker onset depending on sleep needs.
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