STEM-Talk

Episode 168: Alessio Fasano discusses celiac disease and gluten-related disorders

May 22, 2024
Dr. Alessio Fasano, expert in celiac disease and gluten disorders, discusses gluten sensitivity affecting 20 million Americans. He shares insights on microbiome, intestinal permeability, and autoimmune disorders. Alessio talks about a new project studying infants at risk of celiac, published books 'Gluten Freedom' and 'Gut Feelings', and collaborative international research efforts. Additionally, he explores genetic aspects of celiac, complexities of microbiome research, gut permeability biomarkers, and the influence of genes, environment, and microbiome on autoimmune diseases.
Ask episode
AI Snips
Chapters
Transcript
Episode notes
ANECDOTE

Pediatrics Interest

  • Alessio Fasano's interest in pediatrics began in medical school.
  • His mentor highlighted the impact of diarrheal diseases, influencing his career path.
ANECDOTE

Move to Mass General

  • Alessio Fasano moved to the US to study bacteria pathogenesis, staying for 20 years.
  • He later moved his entire lab to Mass General Hospital in a complex operation.
ANECDOTE

Cholera Toxin Discovery

  • While developing a cholera vaccine, Fasano discovered the zonula occludens toxin.
  • This toxin exploits the tight junctions between intestinal cells, causing diarrhea.
Get the Snipd Podcast app to discover more snips from this episode
Get the app