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In this podcast episode, Thomas Serbuchen, the former head of science at NASA, shares insights on leading extremely technical, complex, expensive, and risky projects. He discusses the importance of balancing high-level strategy work with overseeing operations, prioritizing and delegating work, and managing failure to foster learning and innovation. Serbuchen highlights the significance of team efforts and the need for leaders to create a culture that encourages risk-taking and problem-solving. His experience with projects like the James Webb Space Telescope and Mars rover missions exemplifies the impact of effective leadership in pushing the boundaries of scientific exploration.