Episode 15. Management of Newly Diagnosed DLBCL (Including Bonus ASH22 Updates)

In this episode, we discuss the management of newly diagnosed DLBCL with Dr. Pallawi Torka. We also have a few bonus ASH22 updates on DLBCL. Links to articles and abstracts discussed in the episode are as follows: 

1. A comprehensive review article on DLBCL:

https://pubmed.ncbi.nlm.nih.gov/33657296/

2. RCT testing CHOP vs Three Intensive Regimens in DLBCL:

https://www.nejm.org/doi/full/10.1056/nejm199304083281404 

3. RCT testing R-CHOP vs CHOP in DLBCL in older adults:

https://www.nejm.org/doi/full/10.1056/nejmoa011795 

4. RCT testing R-CHOP vs CHOP in young (MINT):

https://pubmed.ncbi.nlm.nih.gov/21940214/ 

5. PHOENIX trial: R-CHOP +/- Ibrutinib:

https://pubmed.ncbi.nlm.nih.gov/30901302/

6. R-CHOP +/- Lenalidomide (ECOG-ACRIN E1412):

https://pubmed.ncbi.nlm.nih.gov/33555941/ 

7. R-CHOP vs Pola-R-CHP (POLARIX Trial):

https://www.nejm.org/doi/full/10.1056/NEJMoa2115304

8. Comparison of 3 IPI scores in DLBCL:

https://ashpublications.org/blood/article/135/23/2041/452696

9. RCT testing R-CHOP vs Dose-Adjusted R-EPOCH (CALGB 50303):

https://ascopubs.org/doi/full/10.1200/JCO.18.01994

10. Timing of CNS Prophylaxis in DLBCL:

https://pubmed.ncbi.nlm.nih.gov/34995350/

11. RCT testing R-CHOP vs R-CHOP + Bortezomib (REMoDL-B):

https://pubmed.ncbi.nlm.nih.gov/30948276/

12. Interim PET in DLBCL? 

https://ashpublications.org/bloodadvances/article/5/9/2375/475850

13. RCTs in Limited Stage DLBCL:

CHOP x 8 vs CHOP x 3 + XRT (S8736):

https://ascopubs.org/doi/10.1200/JCO.2015.65.4582

CHOP x 4 + Rituximab x 6 vs R-CHOP x 6 (FLYER):

https://pubmed.ncbi.nlm.nih.gov/31868632/

PET-adapted therapy with R-CHOP (S1001):

https://pubmed.ncbi.nlm.nih.gov/32658627/

14.   ASH 2022 updates:

REMoDL-B update: https://ashpublications.org/blood/article/140/Supplement%201/1770/493225

Glofitamab update: https://ashpublications.org/blood/article/140/Supplement%201/1062/491024

Epcoritamab update: https://ashpublications.org/blood/article/140/Supplement%201/9443/488543