

Why We Die—And How We Can Live Longer, with Nobel Laureate Venki Ramakrishnan
Apr 18, 2024
Nobel Laureate Venki Ramakrishnan discusses aging, immortality, and the $30 billion longevity industry. Topics include DNA damage, telomeres, caloric restriction, stem cell reprogramming, and ethical considerations in anti-aging advancements.
AI Snips
Chapters
Transcript
Episode notes
Lifespan Variation Insights
- Lifespans vary enormously among species despite similar biological material.
- This suggests we might be able to influence our own aging processes.
DNA Damage Disrupts Aging
- DNA damage accumulates and disrupts the protein orchestra that sustains life.
- This leads to cellular dysfunction which manifests as aging.
DNA Damage and Senescent Cells
- Cells respond to DNA damage by either dying or entering senescence.
- Senescent cells secrete inflammation signals, accumulating with age and causing chronic inflammation.