Big Brains

Why We Die—And How We Can Live Longer, with Nobel Laureate Venki Ramakrishnan

Apr 18, 2024
Nobel Laureate Venki Ramakrishnan discusses aging, immortality, and the $30 billion longevity industry. Topics include DNA damage, telomeres, caloric restriction, stem cell reprogramming, and ethical considerations in anti-aging advancements.
Ask episode
AI Snips
Chapters
Transcript
Episode notes
INSIGHT

Lifespan Variation Insights

  • Lifespans vary enormously among species despite similar biological material.
  • This suggests we might be able to influence our own aging processes.
INSIGHT

DNA Damage Disrupts Aging

  • DNA damage accumulates and disrupts the protein orchestra that sustains life.
  • This leads to cellular dysfunction which manifests as aging.
INSIGHT

DNA Damage and Senescent Cells

  • Cells respond to DNA damage by either dying or entering senescence.
  • Senescent cells secrete inflammation signals, accumulating with age and causing chronic inflammation.
Get the Snipd Podcast app to discover more snips from this episode
Get the app