Arturo Casadevall, a microbiology professor at Johns Hopkins, warns of a looming fungal pandemic similar to the one in 'The Last of Us.' He discusses how climate change is enabling fungi to adapt and resist treatments, posing a serious public health threat. Casadevall emphasizes the need for preparedness through awareness, vaccines, and innovative pharmaceuticals. He also highlights the unique roles that fungi play in our ecosystem, including their potential for sustainable technologies, and stresses the urgency of addressing fungal resistance before it's too late.

In this engaging conversation, Jonah Berger, a renowned Professor at The Wharton School and author of "Magic Words: What to Say to Get Your Way," delves into the transformative power of language. He discusses how specific word choices can strengthen resolutions and enhance communication. Berger unveils various 'magic words' that can help with persuasion and accountability, exploring how language affects our habits and relationships. Plus, he shares intriguing insights on how questions and language tense can significantly impact social dynamics.

Tim Stockwell, a scientist at the Canadian Institute for Substance Use Research and a psychology professor, challenges long-held beliefs about alcohol's health benefits. He reveals how flawed studies have misled the public, suggesting that even moderate drinking may reduce life expectancy. Stockwell discusses the growing societal skepticism towards alcohol, particularly among younger generations embracing sober lifestyles. He emphasizes the risks associated with drinking, including links to cancer, and advocates for stronger public health policies to regulate alcohol consumption.

In this engaging discussion, Sam Parnia, an Associate Professor of Medicine at NYU Langone and author of Lucid Dying, challenges our understanding of death. He explores revolutionary research that suggests the possibility of reviving those declared dead and delves into intriguing near-death experiences that reveal heightened brain activity at life’s edge. Parnia raises profound ethical questions, discusses the evolving perceptions of consciousness, and underscores the significance of scientific inquiry in redefining life, death, and our purpose.

Adam Mastroianni, a psychologist and postdoctoral research scholar at Columbia Business School, explores the intriguing notion of moral decline. He questions whether perceptions of increased meanness are valid or merely illusions fostered by cognitive biases. Mastroianni dives into historical perspectives on morality, revealing that feelings of decline often overshadow evidence of cooperative behavior. He argues for focusing on real social issues rather than unfounded fears, and suggests reducing news consumption for better mental well-being.

J. Doyne Farmer, a complexity scientist and professor at Oxford, once outsmarted casinos with his scientific insights. He dives into the intriguing idea of predicting economies like weather patterns, using chaos theory and big data. Farmer discusses the potential of agent-based modeling to revolutionize economic forecasting and addresses the challenges of understanding complex systems. He also highlights how complexity economics could reshape public policy, tackle climate issues, and pave the way for sustainable growth in our unpredictable world.

Emily Rogalski, a neurology professor at the University of Chicago and a leading expert on 'SuperAgers,' shares insights into the remarkable individuals over 80 who exhibit memory capabilities similar to those in their 50s. She reveals how these 'SuperAgers' defy aging stereotypes through unique cognitive traits and lifestyle choices. The discussion touches on the myths of brain aging, the impact of social connections, and the importance of engaging activities that contribute to maintaining mental health and cognitive function well into old age.

James A. Robinson, a University of Chicago professor and 2024 Nobel laureate in Economic Sciences, explores what drives national success or failure. He discusses the significant role of political and economic institutions using examples like Nogales, Arizona, and Nogales, Mexico. Robinson dives into the balance between liberty and governance while examining the dynamics of states in transition. He also shares insights on tailoring economic advice to diverse local contexts and reflects on the process of envisioning ideal societies based on historical lessons.

Wendy Freedman, a leading astronomer from UChicago, dives into the captivating debate on the universe's age and expansion. She reveals how conflicting measurements of the Hubble constant challenge our understanding of physics. Freedman's groundbreaking research with the James Webb Space Telescope promises to shed light on these mysteries. The discussion also touches on dark matter, dark energy, and the tantalizing possibility of extraterrestrial life, all while encouraging new scientists to tackle the cosmos' biggest questions.

Cathy Cohen, a renowned political scientist at the University of Chicago, delves into the critical role of young voters in shaping elections. She discusses the groundbreaking GenForward Survey, revealing the unique perspectives and priorities of diverse young voters, especially those of color. Cohen uncovers the discontent young voters feel toward major parties and emphasizes their focus on economic issues like inflation and housing. She highlights the importance of tailored messaging and social media engagement to mobilize this pivotal demographic for upcoming elections.