
Big Brains
Big Brains explores the groundbreaking research and discoveries that are changing our world. In each episode, we talk to leading experts and unpack their work in straightforward terms. Interesting conversations that cover a gamut of topics from how music affects our brains to what happens after we die.
Latest episodes

May 29, 2025 • 26min
Inside The Disease That Changes Your Personality, with Bruce Miller
When someone we know or love starts to develop psychological issues, we don't often associate it with a form of dementia. However, this trait is one of the most common signs of frontotemporal dementia (FTD) — the most common neurodegenerative disease in people under the age of 65. In his new book, Mysteries of the Social Brain: Understanding Human Behavior Through Science, Dr. Bruce Miller highlights his experiences observing people with FTD and what they have taught him about what he calls the "social brain."Dr. Bruce Miller has been observing people with FTD for decades in the Memory and Aging Center at the University of San Francisco, where he is also Professor of Neurology and the Founding Director of the Global Brain Health Institute. He shares key insights on how to keep our "social brain" healthy and how it can even unlock our creative potential.

May 15, 2025 • 35min
Meet The ‘Planet Hunter’ Searching For Alien Life, with Jacob Bean
Jacob Bean, an astrophysicist from the University of Chicago, is on the frontlines of the quest for extraterrestrial life. He discusses the groundbreaking detection of carbon dioxide on a distant exoplanet, a pivotal moment for astrophysics! Bean explores potentially habitable worlds like K2-18b and debunks false hopes like Gliese 486b. He reflects on the significance of atmospheric analysis in identifying biosignatures and ponders humanity's shared fragility in the vast cosmos, sparking thoughts about our place in the universe.

4 snips
May 1, 2025 • 30min
How To Stop Gun Violence Before It Starts, with Jens Ludwig
Jens Ludwig, a Professor at the University of Chicago and director of the crime lab, dives into the complex world of gun violence. He argues that most shootings stem from impulsive arguments rather than premeditated plans. Ludwig explores stark differences in gun violence rates between similar neighborhoods, attributing these disparities to emotional triggers. He advocates for innovative, data-backed interventions like the 'Becoming a Man' initiative, emphasizing community engagement and youth empowerment as crucial steps toward a solution.

19 snips
Apr 17, 2025 • 34min
Can Your DNA Predict Your Future?, with Dalton Conley
Dalton Conley, a Princeton University sociologist and author of "The Social Genome," discusses the fascinating intersection of DNA and societal outcomes. He reveals how polygenic scores could predict not just physical traits, but also socioeconomic success, relationships, and even your future spouse. Conley dives into the controversial idea of genetic sorting that influences social interactions and raises urgent questions about potential inequalities. He explores the ethical implications of genetic data in areas like dating, healthcare, and education, questioning our trajectory toward a genetically determined future.

15 snips
Apr 3, 2025 • 32min
Can You Really Die of a Broken Heart? The Hidden Dangers of Grief, with Mary Frances O'Connor
Mary Frances O'Connor, a Professor of Psychology at the University of Arizona, offers compelling insights into how grief affects both the mind and body. She discusses the startling link between profound loss and serious health risks, including heart attacks and immune system issues. O'Connor argues for a shift in how society and healthcare view grief, advocating for grief as a medical concern that requires careful attention. Drawing from personal experience, she highlights the need for better support systems and coping strategies for those navigating the complex terrain of loss.

Mar 20, 2025 • 31min
The Science Behind Raising Successful Kids, with Ariel Kalil
Ariel Kalil, a developmental psychologist and professor at the University of Chicago, dives into the pressing educational challenges facing American children. She highlights the widening achievement gap between socio-economic groups and stresses the critical role of parental engagement in nurturing childhood development. Kalil shares fascinating insights into how simple interventions, like just 15 minutes of reading a day, can make a significant difference. She also explores how AI and behavioral economics could offer innovative solutions to support parents navigating rising inequality.

Mar 6, 2025 • 32min
Do Animals Understand Death?, with Susana Monsó
Join Susana Monsó, an Associate Professor at UNED Madrid and author of "Playing Possum: How Animals Understand Death," as she delves into the intriguing question of whether animals comprehend death. The discussion ranges from grieving elephants to ants that remove corpses, revealing complex animal behaviors related to mortality. Monsó shares insights on how pets like dogs react to the loss of their owners and explores the philosophical implications of animal consciousness. Can animals truly grasp their own mortality? This conversation will challenge your perception.

10 snips
Feb 20, 2025 • 35min
Why Measles Is Resurging—And The Rise Of Vaccine Hesitancy, with Adam Ratner
Dr. Adam Ratner, Director of Pediatric Infectious Diseases at NYU and author of "Booster Shots," delves into the alarming resurgence of measles in the U.S. He discusses the dramatic decline in vaccination rates following the COVID pandemic and the rise of vaccine hesitancy. Ratner explains why measles is one of the most contagious diseases, its historical significance, and the crucial role vaccines play in public health. The conversation underscores the urgent need to combat misinformation and rebuild trust in vaccinations to protect children's health.

22 snips
Feb 6, 2025 • 33min
The Little-Known Secrets To A Good Life, with Shigehiro Oishi
Shigehiro Oishi, a University of Chicago psychology professor and expert on happiness, explores the nuanced layers of a fulfilling life. He introduces the concept of 'psychological richness,' where diverse experiences and challenges can offer deeper satisfaction than mere happiness or meaning. Oishi discusses how social connections and everyday joys contribute to this richness, critiquing the prevalent belief that happiness is life's ultimate goal. He encourages embracing novelty and transformative experiences for a more profound sense of fulfillment.

13 snips
Jan 23, 2025 • 30min
How Bioelectronics Could Heal Our Bodies And Minds, with Bozhi Tian
In this engaging discussion, Bozhi Tian, a Professor of Chemistry at the University of Chicago, explores the innovative world of bioelectronics. He reveals how tiny devices could revolutionize medicine, enabling Band-Aids that communicate with our cells and light-powered pacemakers. Bozhi shares insights on designing bioelectronic systems that enhance brain function and tackle antibiotic resistance. He also discusses the ethical challenges of enhancing human capabilities, all while hinting at exciting applications in art and sustainability.