The Joe Rogan Experience

#1670 - David Sinclair

Jun 18, 2021
David Sinclair is a Harvard researcher and author of Lifespan, focusing on aging as a treatable disease. He discusses innovative methods for reversing aging, including epigenetic testing and hyperbaric oxygen therapy. Sinclair delves into the impacts of exercise and diet on longevity, advocating for practices like intermittent fasting. The conversation also covers the controversial drug metformin's potential benefits for health and aging. Sinclair emphasizes the importance of lifestyle choices and scientific communication in promoting long-term wellness.
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ADVICE

Exercise for Longevity

  • Exercise regularly and intensely enough to lose your breath.
  • Incorporate activities like running or biking a few times a week.
ADVICE

Intermittent Fasting for Health

  • Skip meals and avoid constant snacking.
  • Three meals a day plus snacks is detrimental to health and longevity.
INSIGHT

Complacency from Constant Eating

  • Constant eating makes your body complacent, hindering longevity gene activation.
  • These genes provide resilience and fight aging, measurable by a biological clock.
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