Bitesize: How to Reverse Mitochondrial Aging, Boost Energy & Strength – with Dr. Anurag Singh

Jul 11, 2025

Dr. Anurag Singh, a world leader in mitochondrial health and chief medical officer at Timeline Nutrition, joins for a fascinating conversation. They delve into innovative methods for assessing mitochondrial age, like blood-based assays and advanced MRI techniques. Urolithin A, a postbiotic critical for energy production and muscle recovery, takes center stage, along with its synthesis variability influenced by diet. The insights into how gut health affects our energy levels and overall vitality are both enlightening and actionable!

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INSIGHT

Emerging Mitochondrial Age Tests

Mitochondrial health can be assessed by tracking ATP depletion and recovery using specialized MRI during exercise.
Blood-based assays analyzing white blood cell mitochondria are emerging as accessible mitochondrial health tests.

INSIGHT

NAD and Phosphocreatine Role

NAD and phosphocreatine from creatine metabolism are key to mitochondrial function and muscle strength.
Supplementation with creatine supports phosphocreatine levels that boost ATP and muscle longevity.

ADVICE

Supplement with Urolithin A

Consider supplementing with urolithin A, a postbiotic molecule made by gut bacteria from polyphenols.
Urolithin A enhances mitochondrial function, energy, strength, and recovery at the cellular level.

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Angela and Dr Anurag Singh present a bitesixe edition of their conversation focussing upon mitochondrial health and its implications for overall well-being. They discuss the emerging methods for assessing mitochondrial age, including innovative blood-based assays that could soon be available in clinical settings. The conversation highlights the role of urolithin A, a postbiotic derived from the gut microbiome, in enhancing mitochondrial function and energy production

KEY TAKEAWAYS:

Mitochondrial Age Testing: Current methods for assessing mitochondrial health include advanced MRI techniques and the development of blood-based assays
Role of NAD and Phosphocreatine: NAD levels and phosphocreatine from creatine metabolism are crucial for mitochondrial health and muscle longevity
Urolithin A as a Postbiotic: Urolithin A is a postbiotic produced by gut bacteria from the metabolism of polyphenols found in foods like pomegranates and berries
Variability in Urolithin A Synthesis: The ability to synthesise urolithin A varies significantly among individuals, influenced by dietary habits and gut microbiome health

TIMESTAMPS AND KEY TOPICS:

[00:03:20] Urolithin A and mitochondrial health.

[00:05:35] Variance in urolithin A synthesis.

[00:10:39] Urolithin A and athletic recovery.

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ABOUT THE HOST

Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine.

Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out.

The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode.

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