Keeping It Real: Conversations with Jillian Michaels The New Year, New You Masterclass With Dr Gabrielle Lyon
Dec 31, 2025
Dr. Gabrielle Lyon, a physician and author focused on muscle-centric medicine, shares insights on achieving lasting health and vitality. She discusses the importance of muscle as the 'organ of longevity' and its critical role in fat loss and metabolic health. The conversation covers hormone replacement therapies, the benefits of a protein-forward diet, and the latest in peptide treatments. Dr. Lyon emphasizes shifting from traditional dieting to building muscle for optimal aging and energy, making it a must-listen for anyone looking to enhance their well-being.
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Muscle Is The Organ Of Longevity
- Skeletal muscle is an organ system central to metabolic health and longevity rather than just aesthetics.
- Muscle dysfunction underlies diseases like diabetes, cardiovascular disease, and Alzheimer's by disrupting metabolism.
Muscle Drives Whole-Body Metabolism
- Healthy skeletal muscle is the primary metabolic sink for glucose and fatty acids and acts as an amino acid reservoir.
- Peripheral muscle insulin resistance can precede and drive brain insulin resistance and cognitive decline.
From Keto Panic To Protein-Forward Turnaround
- A 50-year-old patient on a high-fat keto diet had metabolic syndrome despite exercise and fear of carbs.
- Reorienting to ~1 g protein per ideal pound, adding carbs, reducing fat improved labs and lost 20+ pounds.