LONGEVITY with Nathalie Niddam #381: Better Than Lasers: NAD+, Spermidine, and Methylene Blue for Youthful Skin | Amitay Eshel and Anastasia Khodzhaeva
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Oct 24, 2025 Amitay Eshel and Anastasia Khodzhaeva, co-founders of Young Goose, delve into the science of youthful skin, emphasizing that it’s more about cellular energy than mere appearance. They discuss the crucial role of NAD+ in skin repair and its decline with age. Spermidine is highlighted for its benefits in autophagy and hydration, showing visible results like reduced wrinkles. They also introduce methylene blue for its mitochondrial advantages and debunk myths around skin longevity. Their insights present a fresh, science-backed approach to skincare.
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Three Pillars Of Skin Health
- Young Goose frames skin health as three pillars: current appearance, resilience, and long-term longevity.
- Short-term cosmetic gains can harm future skin function by creating fibrosis, lymphatic blockage, or rigidity.
Youthful Skin Is An Energy State
- Young Goose calls youthful skin an energy state driven by NAD+ levels and repair capacity.
- By age 50–60 NAD+ declines roughly 50%, reducing repair and flipping epigenetic 'switches' toward aging.
Topical NAD+ Over Systemic For Skin
- Apply NAD+ precursors topically because systemic NAD+ prioritization limits skin delivery from IVs or oral routes.
- Treat the skin directly to restore local NAD+ and support repair processes for appearance and resilience.