Smarter Not Harder Mitochondria & Ketones: Boost Your Energy Smarter | SNH Podcast #147
Oct 29, 2025
Dr. Latt Mansor, research lead at HVMN and an expert in metabolism from Oxford, dives into the fascinating world of ketones and mitochondrial health. They explore how ketones serve as both fuel and signaling molecules, enhancing brain and heart performance. Latt emphasizes the importance of metabolic flexibility for longevity and cognitive clarity. He discusses groundbreaking research linking ketones to Alzheimer's treatment and cardiac health. Insights into using exogenous ketones for energy optimization round out this intriguing conversation.
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Personal Journey Into Metabolic Research
- Latt Mansor described his journey from Malaysia to Oxford driven by family metabolic disease and personal weight challenges.
- He used research and epigenetics to change his health trajectory and pursue metabolic medicine.
Ketones As Purposeful Brain Fuel
- Ketones are natural fuel molecules produced when glucose and glycogen are low to fuel the brain across the blood-brain barrier.
- Exogenous ketones raise blood BHB even without fasting and act as augmentation fuels for cognition and organs.
Ketones And Neuroprotection
- Ketones improve brain network stability on fMRI and may aid clearance of misfolded proteins tied to Alzheimer's.
- They can increase protein insolubility and target autophagy, suggesting neuroprotective signaling roles.