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NAD 101, NMN vs NR, The Best and Cheapest Way To Increase NAD - Dr. Sandra Kaufmann

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Mar 24, 2025

Guest

Sandra Kaufman

Dr. Sandra Kaufmann, a physician and molecular biologist specializing in anti-aging, dives deep into the importance of NAD, a crucial molecule that declines with age. She explains the roles of NAD and its precursors, NMN and NR, in energy production and cellular health. The conversation covers everything from the best ways to supplement for optimal performance to the risks associated with high doses. Kaufmann also shares her personal protocol for maintaining NAD levels, highlighting lifestyle factors and practical advice on supplementation.

01:11:09

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INSIGHT

NAD Is Short‑Lived And Circadian

NAD is nicotinamide adenine dinucleotide and is extremely short‑acting with a half‑life of minutes to hours.
It is produced and used in a circadian pattern so timing matters for effectiveness.

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INSIGHT

Two Fundamental Roles Of NAD

NAD serves two major roles: redox reactions for energy and as a cofactor when broken into parts.
Low NAD impairs mitochondria, glycolysis and the Krebs cycle, reducing cellular energy.

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ADVICE

Support Sirtuins And PARPs While Preventing Depletion

Protect sirtuins and PARPs by preventing NAD depletion because they require NAD to maintain cellular homeostasis and DNA repair.
Support NAD while blocking major NAD‑consuming enzymes like CD38 to preserve function.

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What NAD Is and Why It Matters

01:43 • 13min

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NAD's Role in Energy Production

14:39 • 2min

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NAD and Fatigue in Aging

16:11 • 3min

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Two Functional Categories of NAD

19:15 • 1min

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PARPs, DNA Repair and NAD

20:31 • 1min

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Sirtuins: Cellular Homeostasis Switches

21:55 • 2min

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How the Body Makes and Recycles NAD

24:24 • 4min

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NR vs NMN and Tissue Preferences

28:13 • 3min

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When IV NAD Makes Sense

30:52 • 2min

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Risks of Large NAD Doses and Methyl Depletion

33:14 • 49sec

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Optimal Timing for NAD Supplementation

34:02 • 1min

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Routes: Oral, IM, Liposomal and Extracellular NAD

35:25 • 1min

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CD38: The NAD-Eating Enzyme

36:28 • 56sec

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Blocking CD38 with Apigenin and Green Tea

37:24 • 1min

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Can You Test NAD Levels?

38:34 • 4min

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Lifestyle Ways to Support NAD

NMN/NR, NNMT and Potential Downsides

46:35 • 4min

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Practical NAD Supplement Rotation Strategy

50:46 • 3min

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Niacin as Cheap NAD Precursor

53:56 • 6min

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Where to Source NR, NMN and NAD

01:00:00 • 5min

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Supplement Quality and Third-Party Testing

01:04:50 • 1min

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NAM-Based Products and Combined Formulas

01:05:50 • 3min

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Closing Advice and Next Steps

• Mentioned in 2 episodes

The Kaufmann Protocol: Aging Solutions

Sandra Kaufmann

This book is an addendum to Dr. Kaufmann's original work, expanding on the list of herbals and vitamins and introducing a new systems-based approach for developing personalized longevity protocols. It classifies molecular agents using the Kaufmann Rating system, making the process more user-friendly. The book educates readers on cutting-edge scientific discoveries related to anti-aging and longevity, while also being entertaining and readable.

#27273

• Mentioned in 2 episodes

The Kaufmann Protocol: Why We Age and How to Stop It

Sandra Kaufmann

The Kaufmann Protocol: Why We Age and How to Stop It is the first comprehensive approach to aging that tackles why we age and recommends a strategic, scientific formulation to decelerate the process. The book discusses aging on a cellular level, explaining the seven tenets or categories of aging, such as DNA alterations, mitochondrial energy, and aging pathways. These concepts are presented in both scientific and laymen terms, using analogies to help readers understand the process. The second half of the book reviews the top fifteen molecular agents that curb the aging process, each rated using the Kaufmann Rating system to help readers create personalized regimens. This book is designed to bring practical information to everyday people, taking the science of aging out of the laboratory and into the real world.

NAD is all the rage. Its such a crucial molecule in our body that declines with age. You're probably not sure if you should be taking NAD or a precursor like NMN or NR, and if so, how – do we take supplements, IVs, injectables…? But you may have also heard of the dangerous pathways that some of these molecules take us down that increases the risk for cancer. So is there a better way? Yes!

Molecular biologist Dr. Sandra Kaufmann, who is completely unbiased, clears the confusion and helps us navigate this world of NAD. It gets a little geeky, so break out your pen and paper, and keep the speed on 1x.

We cover:

- NAD basics

- What is NAD vs NAD+ vs NAD- minus

- Different categories of what NAD does

- How NAD controls circadian rhythms

- Is fatigue due to NAD or something else?

- Is it better to optimize our ovaries with NAD or HRT?

- If, how and when to take NAD, NMN, NR and which one is best?

- The best time to take NAD or its precursors

- When is the only time to do an NAD infusion

- What happens to our DNA when NAD is low

- How NAD can be made from scratch in the body

- The dangers of NAD and its precursors that may triggering more inflammation

- Can you test NAD levels?

- Best way to increase NAD levels naturally

- The cheapest way to increase NAD levels

- What Dr. Sandra does personally for her NAD

Dr. Sandra Kaufmann started her career in the field of cellular biology. She got her Master's Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. And then she turned to medicine, and got her medical Degree at the University of Maryland. And for the last nearly decade she has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children's Hospital in Florida. Everyone in the biohacking world knows Dr. Kaufmann and outside of this world she's been recognized as "Best in Medicine" by the American Health Council.

PAST EPISODES

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Contact Dr. Sandra Kaufmann:

Website: kaufmannprotocol.com

Instagram kaufmannantiaging

Facebook: Kaufmann Anti-Aging Institute

Email: kaufmannaai@gmail.com

Book 1: The Kaufmann Protocol: Why We Age and How To Stop It

Book 2 : The Kaufmann Protocol – Aging Solutions

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