The Immunology Podcast

Ep. 106: “Innate Lymphocytes” Featuring Dr. Arthur Mortha

Jun 3, 2025
Guest
Arthur Mortha
Dr. Arthur Mortha, an Associate Professor at the University of Toronto, shares his insights on innate lymphoid cells and their fascinating connection to the gut microbiome. He discusses how these gut organisms can influence respiratory disease. The conversation also touches on the unexpected role of serotonin in cancer immunotherapy, the unique presence of T cells in the brain, and the intriguing influence of gut microbes on overall health. This engaging dialogue blends expert knowledge with personal anecdotes, making complex science accessible and entertaining.
Ask episode
AI Snips
Chapters
Transcript
Episode notes
INSIGHT

Gut Protist Regulates Lung Immunity

  • A gut commensal protist influences lung immunity through complex cross-organ communication.
  • This involves adaptive and innate immune cells coordinating signals beyond local infection sites.
INSIGHT

ILC2 Migration via S1P Receptors

  • ILC2s use sphingosine-1-phosphate receptors, especially S1PR4, to migrate between gut and lungs.
  • This migration shapes lung immune responses, priming for allergy development when exposed to allergens.
INSIGHT

Microbiota Diversity's Dual Impact

  • Complex microbiota diversity educates the immune system, enhancing pathogen defense.
  • However, elevated immune activation can worsen chronic inflammatory diseases like asthma.
Get the Snipd Podcast app to discover more snips from this episode
Get the app