
unPAUSED with Dr. Mary Claire Haver Strong Bones, Strong Body, Stronger Second Half with Dr Jocelyn Wittstein - Part 2
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Jan 22, 2026 Dr. Jocelyn Wittstein, an orthopedic surgeon from Duke University and co-author of The Complete Bone and Joint Health Plan, shares vital insights on women's musculoskeletal health during menopause. She discusses how exercise significantly reduces fracture risk, regardless of bone density declines. Key topics include the importance of estrogen, the role of testosterone in arthritis, and the necessity of an anti-inflammatory diet. Wittstein emphasizes practical step-by-step protocols, highlighting that a balanced lifestyle is crucial for maintaining strong bones and joints.
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Hormones Modulate Central Pain
- Estrogen and progesterone likely create an endogenous analgesic effect in central pain pathways.
- This may explain increased diffuse pain and fibromyalgia diagnoses in menopausal women.
Testosterone May Affect Female Arthritis Risk
- Lower testosterone in women correlated with higher risk of knee and hand arthritis in large cohort data.
- Dr. Jocelyn Wittstein is testing whether sex hormones change early cartilage resiliency using MRI loading–rebound protocols.
Measuring Cartilage Resilience With MRI
- Cartilage resiliency can be measured by MRI before and after a 30-minute walk to see rebound time.
- Dr. Jocelyn Wittstein hypothesizes estradiol/progesterone preserve cartilage rebound and may prevent arthritis.


