Performance Intelligence Top 3 of 2025: The Science of Gut Microbiome and how it Controls Your Brain | Dr Tom Buckley
Jan 7, 2026
Dr. Tom Buckley, an Associate Professor specializing in precision medicine and gut microbiome research, shares groundbreaking insights on how our gut health influences our energy and brain function. He discusses the complexities of the microbiome and personal experiences with dysbiosis, along with practical dietary advice like embracing a Mediterranean diet and focusing on fiber. Fascinatingly, he highlights how moderate coffee can benefit gut diversity, and explains the science behind fecal transplants and their mood-enhancing effects.
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Microbes Outnumber Our Cells
- We harbour ~40–50 trillion bacterial cells that outnumber our human nucleated cells and shape physiology.
- Gut microbes concentrate where immunity and enteric neurons exist, linking digestion to systemic health.
Dr Tom's Personal Gut Reset
- Dr Tom described his own dysbiosis diagnosed by a specialist and treated with targeted antibiotics and probiotics.
- He reports lasting improvement in blood markers, mood and energy after treatment.
Gut Bacteria Affect Brain Chemistry
- Gut microbes influence serotonin production and therefore mood, sleep and cognition.
- Modifying gut bacteria can change systemic markers that clinicians attribute to liver or hormonal issues.