The High Performance Podcast World’s #1 Longevity Expert: What Fitness & Diet Should Look Like After 30 | Peter Attia (E385)
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Jan 12, 2026 
Dr. Peter Attia, a leading physician in longevity, shares his insights on living longer and healthier. He emphasizes the importance of exercise, particularly strength training, for preserving independence as we age. Peter discusses promising metabolic drugs that can support heart health and cognition while debunking health fads. He introduces the concept of 'backcasting' to guide health decisions today for future well-being. With practical advice on diet, supplements, and emotional health, Peter lays out a comprehensive framework for enhancing longevity.
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Metabolic Drugs Extend Beyond Weight Loss
- GLP-1 and GIP metabolic drugs do more than weight loss and may protect against heart disease and dementia independent of weight change.
- Future drugs targeting sarcopenia may let older people preserve lean mass even without intensive training.
Don't Replace Training With Drugs
- Use metabolic drugs as tools, not replacements for exercise, and prefer lower sustained doses with supervised guidance.
- Combine therapy with resistance training to avoid disproportionate lean-mass loss during rapid weight loss.
Test Testosterone Before Considering TRT
- Test testosterone levels but avoid overprescribing; use TRT mainly when low levels persist despite good lifestyle habits.
- Replace to physiologic levels to improve training capacity, not as a cure for poor sleep, diet, or stress.