
This Podcast Will Kill You
Ep 131 Parkinson’s Disease: Dopamine & discoveries
Dec 12, 2023
Explore the dimensions of Parkinson's disease, including its biology, history, and promising research. Learn about the personal journey of a doctor living with Parkinson's and the challenges they faced. Delve into the symptoms, variability, and diagnostic challenges of the disease. Discover the historical origins of Parkinson's and the discovery of dopamine. Uncover advancements in research and advocacy for Parkinson's disease. Understand the increasing incidence and global burden of the disease.
01:42:11
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Quick takeaways
- Parkinson's disease is characterized by the degeneration of dopaminergic neurons in the substantia nigra, leading to impaired motor function and other non-motor symptoms.
- The primary treatment for Parkinson's disease involves replenishing dopamine levels in the brain through the administration of L-DOPA and carbidopa.
Deep dives
Parkinson's Disease: A Historical Perspective
Parkinson's disease was described in ancient texts and recognized by famous historical figures such as Galen and Leonardo da Vinci. However, it wasn't until James Parkinson's 1817 publication, "Essay on the Shaking Palsy," that the disease received its name. Jean-Martin Charcot later added to the description of Parkinson's disease and suggested that it be named after Parkinson instead of shaking palsy due to a more comprehensive understanding of its symptoms. Research by Constantine Tretiakov provided the connection between the substantia nigra and Parkinson's disease, while the discovery of dopamine and L-DOPA paved the way for the treatment of the condition.
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