The Jesse Chappus Show 677: You Won't Fix Insulin Resistance Until You Do This... | Dr. Annette Bosworth
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Nov 4, 2025 Dr. Annette Bosworth, known as Dr. Boz, is an expert in metabolic and brain health. In this enlightening discussion, she breaks down how insulin resistance drives weight gain and disease. She prescribes a low-carb diet to kickstart ketogenesis and discusses the critical role of magnesium for mitochondrial health. Dr. Bosworth also shares tips on time-restricted eating and reveals her personal success with shedding pounds. Plus, she highlights the importance of monitoring glucose for women facing insulin resistance!
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Start With 20g Carbs And Exogenous Ketones
- Do start with 20 total carbohydrates per day for one week to prove commitment and lower insulin quickly.
- Sip exogenous BHB ketones during the transition to reduce keto flu and signal the liver to make ketones by day four.
Insulin Dictates Metabolic Aging
- Insulin is the main hormone driving chronic aging-like changes and fat storage in midlife.
- Lowering insulin by changing diet restarts mitochondria and cellular fuel use.
Use High-Fat Meals To Stabilize Energy
- Do prioritize high-fat meals (≈80% calories) early to supply ketone substrate and blunt hunger.
- Expect early benefits: better sleep, lower blood pressure, and improved cognition within 10–14 days.