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The Stem Cell Podcast
Ep. 262: “Glia in the Gut” Featuring Dr. Marissa Scavuzzo
Mar 5, 2024
Explore the role of glial cells in the gut and their impact on intestinal motility. Learn about the research on astrocytes in organoids and their function. Discover advancements in bone marrow organoids modeling hematopoietic development and lymphoma organoids for targeted cancer treatments. Dive into the challenges and successes of creating graftable hematopoietic stem cells. Delve into the importance of diversity and authentic problem-solving in science.
01:15:03
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Quick takeaways
- Enteric glial cells have diverse morphologies and include specialized hub cells regulating intestinal motility.
- Microfluidic biochips demonstrate how biomechanical input impacts glial cells, revealing a feedforward mechanism for motility regulation.
Deep dives
Identification of Functionally Specialized Subtypes of Enteric Glial Cells
Enteric glial cells, situated throughout the gastrointestinal system, were shown to have diverse morphologies. Using single-nucleus RNA sequencing, a subset called hub cells was identified, with a unique role in coordinating intestinal motility. These hub cells express mechanosensory channels, like Pizzo2, likely involved in sensing force and transmitting signals for regulating motility.
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