Modeling Bone Marrow Niche with Human Organoids

The chapter explores the development of bone marrow organoids from human induced pluripotent stem cells as a novel model to study hematopoiesis and hematological malignancies. It discusses the challenges and advancements in creating graftable hematopoietic stem cells, highlighting the potential of these organoids in advancing stem cell research. Additionally, it delves into the use of patient-derived primary lymphoma organoids for targeted treatments and precision medicine efforts in cancer therapy.