Unlocking Astrocyte Generation Challenges

This chapter explores the obstacles in generating astrocytes from stem cells, emphasizing the need for efficient acquisition of glial competency in human organoids. It discusses a protocol inducing a gliogenic switch to accelerate differentiation and transplant studies revealing the generation of various cell types. Mechanistic advances in identifying crucial signaling factors for neurodegenerative diseases and the role of spatial transcriptomics in enhancing cellular information visibility are also highlighted.