JAMA Clinical Reviews From the JAMA Network: JAMA Research of the Year With Editor in Chief Kirsten Bibbins-Domingo
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Dec 26, 2025 Kirsten Bibbins-Domingo, a physician-scientist and Editor-in-Chief of JAMA, joins Jennifer Abbasi to unveil the journal's Research of the Year. They explore significant topics such as groundbreaking studies on hypertension and heart failure, the impact of lifestyle interventions on cognitive decline, and the benefits of real-world evidence in clinical trials. Kirsten also highlights a crucial shingles vaccine study linked to dementia and discusses the implications of AI in healthcare research. Their insights provide a fascinating glimpse into the year's most impactful findings.
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Research Mirrors Hot Clinical Areas
- JAMA's selected studies reflect hot clinical areas and novel methods shaping practice.
- They show real-world evidence and innovative methods are increasingly driving impactful research.
Trial Emulation Strengthens Real-World Evidence
- Clinical-trial-emulation studies use observational data with advanced methods to address causal questions.
- Such real-world analyses can complement trials and increase clinician confidence in new therapies.
Quasi-Experimental Vaccine Analysis
- Quasi-experimental designs reduce healthy-vaccinee bias by exploiting eligibility cutoffs.
- Comparing groups distinguished only by birthdate yields more credible vaccine–dementia associations.