Ep. 115: LMHR & The Lipid Energy Model: Implications For Metabolism & Hormones
May 10, 2024
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Discussion on high LDL cholesterol on a low-carb diet, Lean Mass Hyper-Responder (LMHR) phenotype, and Lipid Energy Model. Challenging mainstream views on cholesterol and heart disease. Adapting to lack of carbohydrates and elevated cholesterol levels. Implications for metabolism, hormones, and cardiovascular health.
The Lean Mass Hyper-Responder (LMHR) phenotype challenges mainstream views on cholesterol as it may not directly lead to heart disease.
The Lipid Energy Model highlights stress hormone impact on fat utilization, questioning sustainability of low carb diets.
Understanding metabolic nuances beyond LDL elevation is crucial for long-term health outcomes in low carb high fat diets.
Deep dives
Overview of Lean Mass Hyper Responder Phenotype and Lipid Energy Model
The podcast delves into the lean mass hyper responder phenotype and lipid energy model proposed by Dave Feldman, highlighting the metabolic state of individuals experiencing high LDL cholesterol, high HDL cholesterol, and low triglycerides on a low carb diet. The discussion focuses on the implications of this lipid profile on cardiovascular disease and challenges the conventional understanding of elevated LDL cholesterol in the context of bioenergetic perspectives.
Hormonal Regulation and Thyroid Function in the Model
The podcast addresses the role of stress hormones like glucagon, epinephrine, and cortisol, along with decreased insulin signaling in promoting free fatty acid release for fat utilization in the lipid energy model. Moreover, the discussion highlights the relevance of lowered T3 levels in individuals following a low carb diet and the impact on cholesterol uptake, emphasizing the multi-faceted effects beyond LDL elevation.
Considerations on Long-Term Health and Metabolic Dynamics
The conversation explores the potential implications of long-term adherence to a low carb high fat diet, pointing out the broader metabolic effects and stress responses induced by hormonal shifts and decreased thyroid hormone levels. It questions the sustainability and health optimization of such dietary patterns, underlining that while LDL elevation may not directly lead to heart disease, the overall metabolic state may not be conducive to long-term vitality.
Analysis of Physiological Versus Pathological State in Lipid Energy Model
Examining the distinction between physiological and pathological states brought by the lipid energy model, the podcast cautions against equating the absence of cardiovascular risk with the promotion of optimal health, highlighting the need to evaluate the stress-induced metabolic changes and potential long-term consequences of prioritizing fat oxidation over other metabolic pathways. Emphasizing that while the model may not fuel cardiovascular disease, it may not optimize overall health outcomes.
Conclusion and Recommendations for Dietary Choices
The episode concludes by emphasizing the importance of understanding the metabolic ramifications of dietary approaches like low carb high fat diets, shedding light on additional considerations beyond LDL cholesterol in the quest for long-term health. It advocates for an integrated view that evaluates hormonal regulation, metabolic dynamics, and thyroid function to make informed decisions regarding dietary choices and their impact on overall well-being.
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-115-lmhr-and-the-lipid-energy-model-implications-for-metabolism-and-hormones
Timestamps:
0:00 – intro
1:14 – what is the Lean Mass Hyper-Responder (LMHR) phenotype
3:33 – how the Lipid Energy Model challenges the mainstream dogmatic view linking high cholesterol levels to heart disease
6:33 – the protective effects of cholesterol and why it does not cause heart disease, despite being necessary for atherosclerosis
9:49 – the distinction between Lean Mass Hyper-Responders and those with high cholesterol levels in the context of metabolic dysfunction
15:10 – what is the Lipid Energy Model
22:10 – how the body adapts to a lack of carbohydrates, leading to elevated cholesterol levels
27:22 – the hormonal and metabolic state underlying the Lean Mass Hyper-Responder phenotype
32:21 – how adding carbohydrates lowers cholesterol levels in those who don't have metabolic dysfunction at a cellular level
37:11 – whether Lean Mass Hyper-Responders are at increased risk of cardiovascular disease
42:00 – why the Lean Mass Hyper-Responder phenotype isn't ideal: stress and low thyroid function
51:10 – the parallels between the lipid energy model and physiological insulin resistance
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