The Immunology Podcast cover image

The Immunology Podcast

Ep. 23: “Dendritic Cells and the Immune System” Featuring Dr. Caetano Reis e Sousa

Feb 15, 2022
Dr. Caetano Reis e Sousa discusses dendritic cells, cross-presentation mechanisms, RNA interference, dendritic cell progenitors in influenza. The podcast also covers T-cell reactivity to Omicron, CAR T-cell therapy success, vimentin's role in SARS-CoV-2 entry, CRISPR in T-cell engineering, IKZF3 gene regulation in interferon production, and the continuum of science, art, and humanities.
01:06:28

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Quick takeaways

  • Dendritic cells are activated by specific receptors recognizing dead cell remnants and exposed F-actin for cross-presentation.
  • Alternative spliced form of Dicer, AVID, enhances antiviral RNA interference potential, suggesting targeting AVID can boost immune responses.

Deep dives

Signaling Pathways in Dendritic Cells Triggered into Action by Molecular Pathways

Dendritic cells are crucial for immune responses, with Dr. Keitano Reyes-Esusa discussing their activation. They are mobilized by specific receptors recognizing dead cell remnants and exposed F-actin to facilitate cross-presentation. The importance of understanding dendritic cell functions, especially in cancer immunity, unveils mechanisms like gelsolin regulating cross-presentation efficiency.

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