The Art of Being Well The New Microbiome-Metabolism Science & The GLP-1 Connection You Need to Know | Colleen Cutcliffe
Sep 25, 2025
Colleen Cutcliffe, PhD, co-founder of Pendulum and a leading microbiome scientist, dives into the incredible connections between gut health and metabolic well-being. She explains how keystone strains like Akkermansia muciniphila influence GLP-1 levels and highlight the role of diet in shaping our microbiomes. Colleen discusses the impact of antibiotics on gut resilience, the benefits of fermented foods, and natural ways to enhance GLP-1 signaling. Tune in to discover how gut health can transform your hormones, cravings, and overall vitality!
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Resilience Defines A Healthy Microbiome
- A healthy microbiome equals resilience: ability to handle travel, stress, new foods, and aging without chaos.
- Certain keystone strains like Akkermansia have outsized roles in gut lining integrity and metabolic signaling.
Antibiotics Can Reshape Metabolic Risk
- Antibiotics act like a bomb to the gut, often destroying entire microbial communities.
- Post-antibiotic microbiomes commonly reassemble into profiles that increase obesity and metabolic risk.
Feed Your Microbiome On Purpose
- You control your microbiome by choosing what you feed it through your diet.
- Change diets and your microbiome shifts within weeks, so choose foods that support desired microbes.