The Carlat Psychiatry Podcast Folate and Depression
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Apr 28, 2025 Dive into the fascinating link between low folate levels and depression, tracing discoveries back to the 1930s. Discover how folate impacts neurotransmitter production and cognitive health. Unearth the advantages of L-methylfolate over traditional folic acid, revealing its unique ability to cross the blood-brain barrier. Learn about the effects of folate deficiency on mental health, especially in relation to obesity and inflammation. This discussion highlights the evolving strategies in depression treatment and the emerging importance of affordable folate options.
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Folate Deficiency and Depression
- Folate deficiency is linked to depression and poor antidepressant response.
- Low folate raises homocysteine, promoting depression and vascular issues.
L-methylfolate Best for Depression
- L-methylfolate is the most effective form to treat depression.
- Folic acid and folinic acid are precursors converted by MTHFR enzyme, less effective especially in some genetic variants.
Effective L-methylfolate Dosage
- L-methylfolate augmentation has moderate effect size like atypical antipsychotics and lithium.
- 15 mg is more effective than 7.5 mg for depression treatment.