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Folate and Depression

The Carlat Psychiatry Podcast

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Understanding the Role of L-Methylfolate in Depression Treatment

This chapter explores the crucial role of L-methylfolate in managing depression, emphasizing its unique ability to penetrate the blood-brain barrier and its relevance for individuals with MTHFR enzyme deficiencies. Supported by clinical trials, it discusses L-methylfolate's effectiveness both as an adjunct to antidepressants and as a standalone therapy for specific cases.

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