Understanding Cell Senescence and Aging

Cell senescence is a process where dysfunctional cells cease to divide but do not die, which can contribute to aging. While apoptosis, or programmed cell death, is generally considered a healthy response that allows for stem cells to replace lost cells, senescence allows cells to linger and secrete inflammatory signals known as the senescence-associated secretory phenotype (SASP). This accumulation of senescent cells is gradually more significant as individuals age, especially as the immune system's ability to clear these cells diminishes. The resulting chronic inflammation, termed 'inflammaging,' is linked with various age-related health issues and is considered one of the hallmarks of aging.