Siim Land Podcast #413 Longevity Scientist Breaks Down What Causes Aging of Cells - Matt Kaeberlein PhD
Aug 11, 2024
In this engaging discussion, longevity scientist Matt Kaeberlein delves into the mechanisms of cellular aging. He reveals how senescent cells contribute to chronic diseases and the potential of removing them to enhance health. Kaeberlein explores the immune system's decline with age and its link to inflammation, while discussing promising senolytic therapies. He also highlights the effects of rapamycin on lifespan and the significance of IL-11 in longevity research, providing fascinating insights into the future of healthy aging.
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Senescent Cells and Aging
- Senescent cells are dysfunctional cells that stop dividing but don't die.
- They release inflammatory signals, contributing to aging.
Immune System and Senescence
- As we age, senescent cell burden increases while the immune system's ability to clear them declines.
- This contributes to inflammaging, a chronic inflammatory state linked to aging.
Purpose of Senescence
- Senescence has a purpose, like preventing cancer and aiding wound healing.
- However, age-related immune dysregulation leads to a problematic senescent cell buildup.