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Huberman Lab
Dr. Kyle Gillett: How to Optimize Your Hormones for Health & Vitality
Apr 11, 2022
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02:56:30
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Quick takeaways
- Understand the interaction of behavior, nutrition, exercise, and hormone therapies in optimizing hormone health.
- The six pillars of hormone optimization are diet, exercise, stress management, sleep optimization, sunlight exposure, and spiritual health.
- Hormone levels change throughout different stages of life, emphasizing the need for optimization in both men and women.
- Regular blood tests and careful supplementation are recommended for managing hormone levels.
- Dihydrotestosterone (DHT) plays a role in hair loss, and strategies can be used to optimize its levels.
- Consideration of spirituality is crucial in addressing the interconnectedness of body, mind, and soul in overall health.
Deep dives
Key Point 1: The importance of hormone optimization
Doctor Kile Gallett discusses the significance of hormone optimization and emphasizes the need to understand how various factors such as behavior, nutrition, exercise, and hormone therapies interact to achieve optimal hormone health. He highlights the impact of hormones on mood, mental health, and physical well-being.
Key Point 2: The six pillars of hormone optimization
Doctor Gallett emphasizes the six pillars of hormone optimization, which include diet, exercise, stress management, sleep optimization, sunlight exposure, and spiritual health. These lifestyle factors play a vital role in maintaining optimal hormone levels and overall health.
Key Point 3: Impact of hormonal changes throughout life
Doctor Gallett explains how hormone levels change throughout different stages of life, emphasizing the importance of hormone optimization for both men and women. He discusses the role of hormones like testosterone, estrogen, and progesterone in various aspects of health, including libido, mood, and cognitive function.
Key Point 4: Considerations for hormone management
Doctor Gallett provides insights into the management of hormones, recommending regular blood tests and discussing the impact of certain supplements and medications on hormone levels. He also discusses the role of dihydrotestosterone (DHT) in hair loss and suggests strategies to optimize DHT levels while minimizing negative effects.
Tonga Ali supplementation for hormonal balance
Tonga Ali is a natural herb that has been shown to have a positive effect on testosterone levels. It acts as an aromatase inhibitor, reducing the conversion of testosterone to estrogen. It is often used by both men and women to support hormonal balance. Tonga Ali can be taken continuously for a long period of time, but cycling off for one month every year is recommended for safety.
Phodosia Grestus for boosting testosterone
Phodosia grestus is another herb that has potential benefits for increasing testosterone levels. It acts by increasing luteinizing hormone (LH) release and sensitivity, leading to increased testosterone production. Cycling this supplement by taking it for three weeks and then stopping for one week is recommended. Phodosia grestus can be used by both men and women to support hormonal balance.
Boron for regulating SHBG
Boron is a natural element found in soil and can help regulate sex hormone-binding globulin (SHBG). It can lower SHBG levels, which can result in increased free testosterone. Taking three to six milligrams of boron once or twice a day has been suggested as a dosage. Cycling boron intake may also be beneficial.
Individualized Approach
It's important to note that individual responses to supplementation may vary. Consulting with a healthcare professional and monitoring hormone levels through blood work are crucial to ensure optimal results and minimize potential risks.
The Significance of HC-G in Hormone Regulation
HC-G, or human chorionic gonadotropin, is similar to thyroid-stimulating hormone and plays various roles during pregnancy. It prevents hypothyroidism and aids in maintaining high free T4 levels. HC-G can potentially improve thyroid function and is often prescribed for fertility treatment in both men and women. However, it does suppress LH (luteinizing hormone) levels, and the dose-dependent suppression increases with higher HC-G doses. Some individuals use HC-G to maintain testicular function while on testosterone therapy, but it can also increase estrogen levels. Additionally, HC-G can enhance sensitivity in genitals for both men and women as it interacts with LH receptors in prostate and genital tissue.
The Benefits and Risks of HC-G
HC-G has multiple benefits, including preventing hypothyroidism, aiding in maintaining high free T4 levels, and increasing thyroid function. It is commonly prescribed for fertility treatment in both men and women, typically at a dose of 10,000 units. HC-G can be used alone or in combination with other hormone therapies. However, higher doses can suppress LH production. While HC-G is often considered a non-suppressive alternative to testosterone replacement therapy (TRT), it can suppress LH levels and potentiate estrogen production. HC-G can also improve sensitivity in the genitals for both men and women, enhancing sexual activity.
Understanding Peptides and Their Uses
Peptides are heterogeneous compounds with varying levels of safety and efficacy. Insulin is a peptide that requires medical prescription due to its potency. Other peptides, such as BPC-157 and melanotan, have potential benefits but should also be used with caution. BPC-157 is effective for injuries and inflammatory conditions, while melanotan has FDA approval for hypoactive sexual disorder and lipodystrophy. Peptide usage should be personalized and monitored by a healthcare professional. It is important to be aware of potential side effects and contraindications, particularly for individuals with a family history of melanoma.
The Role of Spirituality in Health
Spirituality plays a vital role in overall health, encompassing physical, mental, and spiritual aspects. One's beliefs and spirituality can impact mental and physical well-being. While personal beliefs vary, it is crucial to recognize the interconnectedness of body, mind, and soul. Physicians should address patients' spiritual health alongside physical and mental health, as all these aspects are interconnected. Patients should have open conversations with their doctors about their spirituality, even if they hold different beliefs. A physician's role is not to pressure patients into any specific beliefs, but to support them in their personal journey.
1.
Introduction
2min
2.
The Huberman Lab Podcast Is Now Partnered With Momentous Supplements
3min
3.
The Sponsors of to Day's Podcast
3min
4.
Thesis Neutropic Starter Kit Review
2min
5.
Hormone Health and Optimization - Doctor Kili Gillett
2min
6.
Preventive Medicine Is Taking Hold in the General Population
2min
7.
Are You Using Home Hormones to Help Men and Women?
5min
8.
How Do You Optimize Your Health?
2min
9.
Is Regular Blood Testing a Good Idea?
1min
10.
Is Coloric Restriction a Good Option for Weight Loss?
4min
11.
Is Intermittent Fasting a Bad Idea for Hormonal Health?
2min
12.
Growth Hormone
2min
13.
Is There Any Aspects of Hormon Optimization That Can Improve Sleep?
4min
14.
Testostro Replacement Therapy Increases Sleep Apnia Risk
3min
15.
Test Astrone and Women
2min
16.
Testostrone and Men
3min
17.
Do You Have Male Pattern Baldness?
2min
18.
Male Pattern Baldness - What Do You Like to See All Men Do to Optimize Dh T?
3min
19.
What Sorts of Things Support Dh T?
2min
20.
Do You Recommend That People Avoid Kirkman and Black Pepper Extract?
5min
21.
Does Creatine Monohydrate Cause Hair Loss?
3min
22.
Male Pattern Baldness
2min
23.
Pc OS Polysistic Verian Cendrome
2min
24.
Symptoms of Pcos
2min
25.
Is There a Treatment for Pc OS?
2min
26.
Oral Contraceptives Are Changing the Way That We Perceive Each Other
4min
27.
Is There a Difference Between a Synthetic Progeston and an Oral Contraception?
1min
28.
Oral Contraception Can Disrupt Fertility
2min
29.
Can Mariwana Reduce Testosterone?
2min
30.
Do You Really Need a Drink?
2min
31.
Do Testostron Supplements Make You More Prone to Prostate Cancer?
3min
32.
Prostate Cancer and Testosterone
2min
33.
Is There Something Wrong With My Prostate?
2min
34.
Is Sal Palmetto a Good Anti Androgen?
2min
35.
Pelvic Floor and Prostate Overtime
3min
36.
Is Dalafill for Prostate Hyperplasia Effective?
3min
37.
Doses to Dalpila
5min
38.
Do You Shout Away From Aromatist Inhibitors?
2min
39.
Calcium Deglucrate Can Help With Growth Hormone
2min
40.
Do I Really Need to Take a Dim to Reduce Estrogen?
3min
41.
Are You on L Carnatine?
2min
42.
Grass Fungated Butter
2min
43.
Are You at Risk of Not Getting Healthy Testostron to Estrogen?
2min
44.
Tonga Ali
2min
45.
Tonga Ali
2min
46.
Can Tonga Ali Be Used for Ton Cat?
2min
47.
Aphodosia Grestus
1min
48.
Do You Recommend This to Men and Women?
2min
49.
Do You Know What Is Boron?
2min
50.
The Risks and Benefits of Taking Human Corionic G
3min
51.
HCG and Silenium - The Best Thyroxine Supplements for Thyroid Health
2min
52.
Can HCG Increase Sensitivity of the Genitals?
2min
53.
Is There a Risk of Dopomin Injection on Pregnancy Tests?
3min
54.
Patuitary Microadnomas - What Are the Causes?
2min
55.
Dopomin Wave Pool
3min
56.
Is Vitam in B Six the Safer Form of the Enzyme?
3min
57.
Can You Get El Carnatine From Food?
3min
58.
Are There Any Benefits to Having a Blood Test?
3min
59.
Relational Effects on Hormones
2min
60.
Do You Have a Crisis in Relationships?
2min
61.
Is There a Relationship That Lasts Longer Than You Think?
2min
62.
Is There Evidence That an Infant Changes?
2min
63.
Is Prolacton a Bad Hormone?
3min
64.
Is Sauna Really Bad for Sperm Production?
2min
65.
Are Peptides Safe?
2min
66.
Insolent and Growth Hormone in Pregnancy
3min
67.
The Risks and Benefits of Growth Hormone
2min
68.
What Is the Best Medication for Cancer?
2min
69.
Is BPC One, Five Seven Approved?
2min
70.
Is There a Prescription for LPS?
2min
71.
Malanitan
3min
72.
The Sixth Pillar - Spirituality
3min
73.
Agnostic or Atheist? What Are the Sixth Pillar Practices?
2min
74.
Is Kafine Problematic for Hormonal Hormones?
2min
75.
Are You Taking Patience?
3min
My guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health and well-being in both men and women. We discuss how to improve hormones using behavioral, nutritional, and exercise-based tools and safely and rationally approach supplementation and hormone therapies. We discuss testosterone and estrogen and how those hormones relate to fertility, mood, aging, relationships, disease pathologies, thyroid hormone, growth hormone, prolactin, dopamine and peptides that impact physical and mental health and vitality across the lifespan. The episode is rich with scientific mechanisms and tools for people to consider.
For the full show notes, visit hubermanlab.com.
Thank you to our sponsors
AG1 (Athletic Greens): https://athleticgreens.com/huberman
LMNT: https://drinklmnt.com/huberman
Supplements from Momentous
https://www.livemomentous.com/huberman
Timestamps
(00:00:00) Dr. Kyle Gillett, MD, Hormone Optimization
(00:03:28) Sponsors: AG1, LMNT
(00:08:24) Preventative Medicine & Hormone Health
(00:14:17) The Six Pillars of Hormone Health Optimization
(00:17:14) Diet for Hormone Health, Blood Testing
(00:20:21) Exercise for Hormone Health
(00:21:06) Caloric Restriction, Obesity & Testosterone
(00:23:55) Intermittent Fasting, Growth Hormone (GH), IGF-1
(00:29:08) Sleep Quality & Hormones
(00:35:03) Testosterone in Women
(00:38:55) Dihydrotestosterone (DHT), Hair Loss
(00:43:46) DHT in Men and Women, Turmeric/Curcumin, Creatine
(00:50:10) 5-Alpha Reductase, Finasteride, Saw Palmetto
(00:52:30) Hair loss, DHT, Creatine Monohydrate
(00:55:07) Hair Regrowth, Male Pattern Baldness
(00:58:12) Polycystic Ovary Syndrome (PCOS), Inositol, DIM
(01:04:00) Oral Contraception, Perceived Attractiveness, Fertility
(01:10:31) Testosterone & Marijuana or Alcohol
(01:14:27) Sleep Supplement Frequency
(01:15:34) Testosterone Supplementation & Prostate Cancer
(01:20:24) Prostate Health, Dietary Fiber, Saw Palmetto, C-Reactive Protein
(01:24:05) Prostate Health & Pelvic Floor, Viagra, Tadalafil
(01:30:54) Testosterone Replacement Therapy (TRT)
(01:35:17) Estrogen & Aromatase Inhibitors, Calcium D-Glucarate, DIM
(01:39:28) Lifestyle Factors to Increase Testosterone/Estrogen Levels, Dietary Fats
(01:45:34) Aromatase Supplements: Ecdysterone, Turkesterone
(01:47:04) Tongkat Ali (Long Jack), Estrogen/Testosterone levels
(01:52:25) Fadogia Agrestis, Luteinizing Hormone (LH), Frequency
(01:56:44) Boron, Sex Hormone Binding Globulin (SHBG)
(01:58:13) Human Chorionic Gonadotropin (hCG), Fertility
(02:04:18) Prolactin & Dopamine, Pituitary Damage
(02:08:34) Augmenting Dopamine Levels: Casein, Gluten, Vitamin E, Vitamin B6 (P5P)
(02:12:30) L-Carnitine & Fertility, TMAO & Allicin (Garlic)
(02:18:19) Blood Test Frequency
(02:19:41) Long-Term Relationships & Effects on Hormones
(02:25:33) Nesting Instincts: Prolactin, Childbirth & Relationships
(02:29:05) Cold & Hot Exposure, Hormones & Fertility
(02:32:34) Peptide Hormones: Insulin, Tesamorelin, Ghrelin
(02:37:24) Growth Hormone-Releasing Peptides (GHRPs)
(02:39:38) BPC-157 & Injury, Dosing Frequency
(02:45:23) Uses for Melanotan
(02:48:21) Spiritual Health Impact on Mental & Physical Health
(02:54:18) Caffeine & Hormones
(02:56:19) Neural Network Newsletter, Zero-Cost Support, YouTube Feedback, Spotify Review, Apple Reviews, Sponsors, Supplements, Instagram, Twitter
Title Card Photo Credit: Mike Blabac
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