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Theory & Application of CAR-T Therapy
Jun 18, 2024
Dr. Max Konig delves into CAR-T Cell therapy, discussing how it's made and administered, risks, side effects, rheumatic diseases it treats, and the ethics and costs involved. Explore the success in treating cancer, risks like cytokine-related toxicities, and the potential for autoimmune diseases. Learn about the evolution of therapies, impact on memory B cells, and advancements in precision immunotherapy for autoimmune diseases.
57:36
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Quick takeaways
- CAR-T therapy shows potential in treating autoimmune diseases by targeting specific cells based on markers.
- Innovative CAR-T enhancements enable effective tumor control and provide avenues for precision immunotherapies in autoimmune disorders.
Deep dives
CAR T-cell Therapy: Transformation in Treating Autoimmunity
CAR T-cell therapy presents a transformative approach in treating autoimmunity, targeting chimeric antigen receptor T cells to eliminate various cell types. The therapy has shown success in targeting malignant B cells in lymphoma and multiple myeloma due to their accessibility and availability of surface markers. By engineering the body's T cells to recognize and kill specific cells based on markers, CAR T-cell therapy creates a promising avenue for treating autoimmune diseases and potentially revolutionizing rheumatology.
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