Confidence is biology you can hack. In this episode, you’ll see how confidence builds inside your brain, rewires through neuroplasticity, and connects directly to mitochondria, metabolism, and human performance. You’ll get tools that reprogram fear, regulate your nervous system, and turn stress into fuel so you build radical confidence that lasts.
Listen to this classic with host Dave Asprey as he talks with entrepreneur, author, and Women of Impact founder Lisa Bilyeu. Lisa went from a stay-at-home “supporting role” to co-founding Quest Nutrition, scaling it into a billion-dollar company, and running a global media empire. She brings years of lived experience and applied mindset training, making her one of the most authentic voices on confidence, resilience, and leadership in the biohacking world.
You’ll learn how to:
• Hack confidence with the same strategies you use for sleep optimization, fasting, and cold therapy
• Spot biological triggers behind fear, self-doubt, and procrastination
• Use repetition and mindset tools to upgrade brain optimization and neuroplasticity
• Turn stress hormones into growth signals for longevity and functional medicine practices
• Reframe trauma and setbacks as power for resilience and high performance
• Support courage and focus with nootropics, ketosis, supplements, and Danger Coffee
This episode shows you how to treat confidence as a trainable skill, not a personality trait. If you want smarter not harder strategies to master your biology, expand your impact, and live with unshakable resilience, you’ll find them here.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.
New episodes release every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.
Keywords: Lisa Bilyeu, Radical Confidence, Quest Nutrition, Women of Impact, confidence training, resilience biohacking, mindset reprogramming, courage hacking, fear rewiring, entrepreneurial mindset, human performance, brain optimization, neuroplasticity tools, mitochondria and confidence, trauma resilience, emotional regulation, nootropics for confidence, stress as fuel, leadership confidence, Human Upgrade podcast
Thank you to our sponsors!
Resources:
• Lisa’s Website: https://lisabilyeu.com/
• Danger Coffee: https://dangercoffee.com/DAVE15
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen: https://40yearsofzen.com
Timestamps:
0:00 – Trailer
0:38 – Intro
2:38 – From Housewife to Entrepreneur
17:52 – Building Impact Theory
27:56 – Radical Confidence
39:14 – The No BS Game
44:45 – Finding Purpose
55:34 – Inner Critic & Competence
1:01:10 – Becoming Your Own Hero
1:08:32 – Boundaries & Relationships
1:09:52 – Conclusion
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The Human Upgrade: Biohacking for Longevity & Performance 
