

Episode 490: JJ Virgin on HRT and Creatine HCL: The Protocol That Actually Works for Women
Oct 3, 2025
In this engaging discussion, JJ Virgin, a 4-time New York Times bestselling author and renowned nutrition expert, dives into the transformative power of hormone replacement therapy (HRT) and creatine HCL specifically for women. She emphasizes the importance of starting HRT at the first signs of hormone shifts. JJ explains why many creatine supplements fail to be absorbed effectively and advocates for creatine's benefits for women over 40, including enhanced energy and brain health. She highlights the significance of tracking body composition over scale weight, showcasing a compelling case study.
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Early HRT Transformed Her Health
- JJ Virgin began hormone replacement when symptoms first appeared in her mid-40s and noticed rapid improvements.
- She credits thyroid, low-dose testosterone, and then estrogen for restoring energy and recovery.
Bad Progesterone Experience Changed Her Approach
- JJ tried progesterone and gained 12 pounds in a week under one doctor's high-dose protocol.
- She now uses low-dose or cycles progesterone and avoids daily high doses because it made her feel bad.
Find A Menopause Specialist
- Find a clinician who specializes in menopause and HRT rather than relying on generalists.
- Test and tailor hormones because dosing and needs vary widely between individuals.