Episode 493: Ben Greenfield: How to Actually Look 20 Years Younger + His Most Extreme Biohacks Revealed

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Oct 14, 2025

Ben Greenfield, a leading biohacker and bestselling author of 'Boundless,' dives into fascinating health optimization strategies. He shares his jaw-dropping experience of spending $40,000 on young plasma replacement therapy that boosted his energy and vitality. Discover the science behind why digestive enzymes are crucial post-40, and his take on why the popular 12-3-30 treadmill trend is overrated. Ben also delves into the potential of GLP-1 microdosing for appetite control, highlighting the importance of balancing biohacking with spirituality.

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ADVICE

Feed Your Brain With The Right Fats

Eat a Mediterranean-style diet rich in oleic acid and DHA to support myelin and brain function.
Supplement with fish oil for DHA and prioritize protein and B vitamins for neurotransmitter support.

ADVICE

Use Digestive Enzymes After 40

Take digestive enzymes with most meals after ~40 to improve protein and nutrient absorption.
If you forget before a meal, take them after to still receive benefits.

ADVICE

Lower Meal Glucose With Simple Agents

Use glucose disposal agents (berberine, bitter melon, apple cider vinegar) to blunt post-meal blood sugar spikes.
Beware strong agents like dihydroberberine can cause hypoglycemia and stomach upset if overused.

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What happens when biohacking's biggest evangelist spends $40,000 replacing his blood with young plasma? In this episode of Habits and Hustle, I sit down with Ben Greenfield, the ultimate biohacker and author of "Boundless," for a deep dive into the science of optimization.

We discuss the real science behind fat loss, his daily skincare routine that keeps him looking decades younger, and why he believes faith is just as important as physical optimization. We also dive into his controversial take on GLP-1 microdosing, why the 12-3-30 treadmill trend is overrated, and how he went from extreme experimenter to finding balance between optimization and spirituality.

Ben Greenfield is a biohacker, human performance consultant, and New York Times bestselling author. He's one of the world's leading experts on performance, recovery, sleep, digestion, brain optimization, and anti-aging. His revised book "Boundless" is considered the encyclopedia of health optimization.

What We Discuss:

(04:00) Why most people need digestive enzymes after 40 and how they unlock nutrients

(18:00) Cold plunging for women: What the research actually shows

(36:00) The 12-3-30 treadmill trend: Why it's overrated for body composition

(51:00) GLP-1 agonists: Why microdosing might be the future of appetite control

(1:05:00) The plasma replacement therapy that cost $40K but made him feel "unstoppable"

(1:27:00) Faith, forgiveness, and finding purpose beyond biohacking

(1:37:00) His anti-aging skincare routine that keeps him looking decades younger

…and more!

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Find more from Jen:

Website: https://www.jennifercohen.com/

Instagram: @therealjencohen

Books: https://www.jennifercohen.com/books

Speaking: https://www.jennifercohen.com/speaking-engagement

Find more from Ben Greenfield:

Instagram: https://www.instagram.com/bengreenfieldfitness/

Website: https://boundlessbook.com/