ACR Journals On Air
ACR Convergence 2024: New Mechanisms in Autoinflammatory Diseases
Nov 16, 2024
Dr. Grant Schulert, an expert in auto-inflammatory disorders and single-cell immune landscape research, joins forces with Dr. Arthur Kaser, a leading figure in inflammatory bowel disease and T-cell priming. They delve into the complexities of systemic juvenile idiopathic arthritis (SJIA) and reveal groundbreaking insights at the single-cell level. The discussion showcases innovative methodologies like UDON and SATAY-UDON, alongside exciting new therapeutic targets for autoinflammatory diseases, igniting curiosity for future advancements in medicine.
30:28
Episode guests
AI Summary
AI Chapters
Episode notes
Podcast summary created with Snipd AI
Quick takeaways
- Single-cell RNA sequencing is revolutionizing the understanding of systemic juvenile idiopathic arthritis by revealing unique cellular behaviors in patient inflammatory responses.
- Research into purine metabolism and T-cell activation is identifying metabolic checkpoints as promising therapeutic targets for improving treatments of autoinflammatory diseases.
Deep dives
Understanding Systemic JIA and Its Complications
Systemic juvenile idiopathic arthritis (JIA) is a complex and heterogeneous disorder characterized by inflammation that extends beyond the joints. It manifests with symptoms such as daily fevers, rashes, and potential systemic complications like macrophage activation syndrome (MAS), which is part of a spectrum of cytokine storm syndromes. While many children improve with biologic treatments, a significant portion experiences refractory disease, complicating management. The clinical diversity within systemic JIA underscores the need for tailored therapeutic strategies and a deeper understanding of varying inflammatory responses in affected patients.
Remember Everything You Learn from Podcasts
Save insights instantly, chat with episodes, and build lasting knowledge - all powered by AI.
