Dr. Grant Schulert, an expert in auto-inflammatory disorders and single-cell immune landscape research, joins forces with Dr. Arthur Kaser, a leading figure in inflammatory bowel disease and T-cell priming. They delve into the complexities of systemic juvenile idiopathic arthritis (SJIA) and reveal groundbreaking insights at the single-cell level. The discussion showcases innovative methodologies like UDON and SATAY-UDON, alongside exciting new therapeutic targets for autoinflammatory diseases, igniting curiosity for future advancements in medicine.