

Show 1188: The Healing Potential of Psychedelic Drugs-LSD Without Hallucinations??
Apr 17, 2025
David Nichols, an authority on hallucinogens from UNC Chapel Hill, and Matthew Johnson, a psychiatric researcher at Johns Hopkins, discuss the evolving landscape of psychedelic therapy. They explore how psychedelics like LSD, traditionally stigmatized, are now being researched for mental health treatment, including addiction and cancer-related distress. Notably, they highlight a modified LSD that lacks hallucinogenic effects but may enhance neuroplasticity. Their insights shed light on the potential revolution in mental health care through these once-taboo substances.
AI Snips
Chapters
Transcript
Episode notes
Albert Hoffman's LSD Discovery
- Albert Hoffman discovered LSD's effects by accident in 1943 after resynthesizing a compound previously deemed uninteresting.
- His famous "bicycle ride" home marked the first human LSD experience, revealing vivid visual hallucinations.
Psilocybin's Rapid Therapeutic Impact
- Single psilocybin treatments with psychotherapy can alleviate existential depression, anxiety, and addictions.
- These therapies offer rapid, lasting effects where conventional treatments often fail.
Shifting Attitudes Towards Psychedelics
- Public and scientific acceptance of psychedelic research has grown dramatically in recent years.
- This shift enables broader investigations and removal of stigma around these compounds.