This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality.For the full show notes, visit hubermanlab.com.Thank you to our sponsorsAG1 (Athletic Greens): https://athleticgreens.com/hubermanLMNT: https://drinklmnt.com/hubermanlabSupplements from Momentoushttps://www.livemomentous.com/hubermanTimestamps(00:00:00) Introducing Dr. Matthew Johnson(00:02:27) Sponsors: AG1, LMNT(00:06:40) ‘Psychedelics’ Defined(00:14:09) Hallucinations, Synesthesia, Altered Space-Time Perception(00:19:56) Serotonin & Dopamine (00:23:50) Ketamine & Glutamate (00:28:00) An Example Psychedelic Experiment(00:37:30) ‘Letting Go’ with Psychedelics(00:44:10) Our Mind’s Eye(00:48:00) Redefining Your Sense of Self (00:58:56) Exporting Psychedelic Learnings to Daily Life(01:04:36) Flashbacks(01:12:10) Ayahuasca, & ASMR, Kundalini Breathing(01:15:54) MDMA, DMT(01:26:00) Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis(01:38:15) Micro-Dosing(01:56:45) Risks for Kids, Adolescents & Teenagers; Future Clinical Trials(02:03:40) Legal Status: Decriminalization vs. Legalization vs. Regulation(02:18:35) Psychedelics for Treating Concussion & Traumatic Brain Injury (02:27:45) Shifting Trends in Psychedelic Research, Academic Culture(02:44:23) Participating in a Clinical Trial, Online Survey Studies, Breathwork (02:50:38) Conclusions, Subscribing & Supporting the HLP, SupplementsTitle Card Photo Credit: Mike BlabacDisclaimer

This episode features a panel that I moderated in front of a standing-room-only crowd at the Milken Institute's Global Conference 2019. It includes a great overview of psychedelic science, investing opportunities, anecdotal personal benefits, legal challenges, and much more. I think it’s one of the more comprehensive panels ever done on the subject. Here are the participants:Matthew Johnson — Principal Investigator, Johns Hopkins Psychedelic Research UnitAyelet Waldman — Author, A Really Good Day: How Microdosing Made a Mega Difference in My Mood, My Marriage, and My LifeRobin Carhart-Harris — Head of Psychedelic Research, Centre for Psychedelic Research, Department of Brain Sciences, Imperial College LondonChristian Angermayer — Founder, Apeiron Investment Group and ATAI Life SciencesPlease enjoy!***If you enjoy the podcast, would you please consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it really makes a difference in helping to convince hard-to-get guests. I also love reading the reviews!For show notes and past guests, please visit tim.blog/podcast.Sign up for Tim’s email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Matthew Johnson is a prolific exited entrepreneur known for transforming the healthcare software sector and leading TruConnect into a telecom powerhouse. In this conversation, he reveals his journey from finance to fulfilling entrepreneurship, emphasizing the importance of work-life balance and family. Matthew shares insights on hiring and management challenges, navigating investment strategies, and raising entrepreneurial children. He also discusses his passion for charity work, illustrating how purpose-driven endeavors provide deeper fulfillment than mere profits.