The Generalist

Shrinking the Gap Between Sci-Fi and Sci-Fact: Josh Wolfe (Co-Founder of Lux Capital)

Apr 15, 2025

Josh Wolfe, co-founder of Lux Capital, dives into futuristic innovations like genetically modified pig organs for transplantation and the groundbreaking technology allowing us to 'teleport' smells. He discusses how these advancements can reshape industries and even lead to life-saving medical solutions. Wolfe emphasizes the role of speculative risks in tech investments and shares insights on identifying market trends. Additionally, he explores the fascinating intersection of comic book lore with biotechnology, promising a thrilling glimpse into the future of science.

01:27:26

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Episode guests

Josh Wolfe

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Quick takeaways

Xenotransplantation utilizing genetically modified pig organs could revolutionize organ transplants, significantly reducing organ shortages and improving patient outcomes.

The digitization of scent through advanced olfactory technology presents opportunities to transform industries, impacting everything from healthcare to fragrance production.

Studying unique genetic traits in isolated populations may lead to crucial medical breakthroughs, while also prioritizing ethical considerations and community support.

Deep dives

The Importance of Anticipating Risks

Anticipating potential failures is crucial in both entrepreneurship and investment. Great entrepreneurs and investors focus on identifying risks, investing time and resources to address these risks before they escalate. This proactive approach not only minimizes losses but also enhances decision-making capabilities. By considering what could go wrong, individuals can strategize effectively and pave the way for success.

Intro

6min

Bridging Science Fiction and Technological Innovation

3min

Advancements in Xenotransplantation

10min

Scent, Memory, and Genetic Innovation

22min

Exploring the Intersection of Comic Book Lore and Advanced Biotechnology

2min

Uncovering Genetic Superpowers

10min

Navigating Macro Trends in Venture Capital

29min

Exploring Human Nature and Future Technologies Through Literature

4min

Josh Wolfe is a co-founder of Lux Capital, where he funds the kinds of ventures that change everything: think gene-edited pig organs and technology that lets you “record” smells. His approach? Relentless curiosity. He reads dozens of newspapers daily to identify patterns, always staying a few steps ahead. In this episode of The Generalist, Josh shares how his firm backs companies that don’t just predict the future, but create it.

In our conversation, we explore:

• The revolutionary development of genetically modified pig organs being transplanted into humans and what this means for the future of organ transplantation.

• The recent achievement of "teleporting smell" across space and why computers that can replicate scents will open up entirely new industries.

• Why Lux is investing in the search for real-life "X-Men" — genetic outliers in isolated populations whose DNA could lead to life-saving medical advancements.

• How Josh evaluates macro trends to make smarter micro investment decisions and why ignoring the big picture is a mistake.

• The three tech sectors that Josh believes will define the geopolitical balance in the decades ahead.

• How Josh stays current on macroeconomic trends.

• Much more

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For a full transcript of the episode, please visit: https://thegeneralist.substack.com/p/shrinking-the-gap-between-sci-fi-and-sci-fact-josh-wolfe

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