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Mastering Nutrition

Glutathione Intolerance: Getting to the Bottom of It | Masterjohn Q&A Files #308

Feb 6, 2023
Explore the causes of glutathione intolerance and learn about various hypotheses and tests to determine the factors contributing to it. Delve into the breakdown and synthesis of glutathione, as well as the metabolism of cysteine. Discover the potential toxic by-products associated with different options for metabolizing cysteine and find out about recommended interventions for glutathione intolerance.
29:30

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Quick takeaways

  • Intolerance to glutathione may be due to imbalanced or exhausted pathways in glutathione metabolism, leading to low levels and causing symptoms like brain fog.
  • The breakdown of glutathione can produce toxic byproducts such as ammonia, propionyl CoA, and hydrogen sulfide, which can impact metabolism and contribute to intolerance.

Deep dives

Understanding why some chronically ill individuals don't tolerate glutathione

Many individuals with chronic illness experience intolerance to glutathione, vitamin C, and other glutathione precursors like NAC and vitamin B6. The intolerance often manifests as extreme brain fog, which seems to worsen with larger glutathione doses. This intolerance may be due to an imbalanced or exhausted pathway in the glutathione metabolism system, leading to low or minimal glutathione levels. Different proportions of glutathione precursors and supporting nutrients may be necessary to improve tolerance. To isolate the source of the problem and explore potential solutions, several home experiments can be conducted. Tests involving L-glutamate, glycine, ammonia reduction, and molybdenum supplementation can help identify specific issues and guide appropriate supplementation strategies.

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