Women Want Strong Men From Replacement to Optimization: A New Era in Testosterone Therapy with Dave Lee
Sep 23, 2025
In this engaging discussion, Dave Lee, a testosterone therapy expert and founder of Victory Men's Health, dives deep into the crucial difference between Testosterone Replacement Therapy and Testosterone Optimization Therapy. He highlights common mistakes in protocols and explains why 99% are inadequate. The conversation covers optimal dosing strategies, injection frequency, and how factors like SHBG affect treatment. Dave also shares insights on recognizing over-optimization signs and offers practical tips for both newcomers and those frustrated with their results.
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Replacement Alone Often Fails
- Most common TRT protocols (pellets, long-ester injections, low-frequency dosing) produce poor outcomes despite raising total testosterone.
- Dave Lee argues replacement often fails because it doesn't optimize physiologic free testosterone and patient experience.
Prefer Scrotal Cream Or Standard Injections
- Use trans-scrotal cream or injections of cypionate/enanthate rather than testosterone gel for better delivery efficiency.
- Prefer a 20% scrotal cream or long-ester injections depending on patient preference and tolerance.
Prescribe Doses In Syringe-Readable Units
- Prescribe injection doses in measurable increments that map to insulin syringe marks to avoid patient dosing errors.
- Explain exactly what each insulin-syringe mark equals in milligrams to improve compliance and accuracy.
