What if one spray could upgrade your brain, protect your mitochondria, and outperform IV therapy and liposomal supplements? In this episode, you’ll discover the breakthrough science behind topical glutathione delivery that uses your skin’s water channels to raise intracellular glutathione levels in just 60 seconds. Learn how this powerful antioxidant works at the cellular level to reduce oxidative stress, support mitochondrial function, and drive real improvements in brain health, emotional resilience, and human performance.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Nayan Patel, a world-leading pharmacist and formulator who pioneered this next-gen delivery method. With over two decades of clinical work in functional medicine, Nayan has helped reshape how we think about glutathione benefits, systemic detox, and performance optimization. His research shows that topical delivery bypasses traditional fat-based absorption, achieving higher brain uptake and faster results than IVs or capsules.
You’ll learn:
• Why glutathione for longevity is foundational to biohacking
• How it protects against cellular inflammation and improves TBI recovery issues
• Why pairing glutathione with NAD+, vitamin C, or pharmaceutical nicotine creates a powerful synergy
• How it preserves NAD+, supports sirtuins, and enhances ATP production
• When to use glutathione as an immune booster for resilience and recovery
This conversation also reveals the truth behind liposomal supplements, how your age affects glutathione absorption, and why this molecule is critical for anyone using nootropics, in ketosis, or pushing metabolic limits.
This episode is essential listening for anyone into biohacking, cold therapy, functional medicine, or RFK-style medical freedom. You’ll walk away with practical tools to boost nitric oxide naturally, prevent dysfunction, and optimize your biology whether you’re on a carnivore diet or just looking for an edge.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
Resources:
• Auro Wellness Website: Use code ‘dave10’ at checkout https://aurowellness.com/
• Dave Asprey’s Website: https://daveasprey.com
• Danger Coffee: https://dangercoffee.com/DAVE15
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Upgrade Collective: https://www.ourupgradecollective.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 00:20 Intro
• 01:12 Water Channel Delivery Explained
• 02:25 What Makes Glutathione Special
• 05:04 Why IVs and Liposomes Fail
• 06:29 Measuring Glutathione in the Brain
• 10:42 Key Benefits and Use Cases
• 20:49 Emotional Resilience Effects
• 23:54 Sensitivity and Response
• 24:55 Best Timing for Use
• 25:53 Workout Performance Boost
• 26:47 Brain Health and TBI Support
• 28:22 Best Stack Combinations
• 29:32 Nicotine + Glutathione Synergy
• 33:18 Longevity, Sirtuins, and Genes
• 40:36 Glutathione as Immune Booster
• 43:15 Peptides and Next-Gen Hacks
• 45:29 Dosing Tips and Wrap-Up
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The Human Upgrade: Biohacking for Longevity & Performance 