Nicotine and Glutathione: Enhancing Cognition and Longevity

This chapter explores the cognitive-enhancing potential of pharmaceutical nicotine, focusing on its benefits in low doses and its synergy with glutathione for better health outcomes. The discussion includes historical contexts, ongoing research into gene expression, and the importance of managing oxidative stress for improved cellular function and longevity. By examining the critical role of glutathione in reducing inflammation and promoting health, the chapter emphasizes the need for careful supplementation and understanding its interactions with other crucial molecules.

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What if one spray could upgrade your brain, protect your mitochondria, and outperform IV therapy and liposomal supplements? In this episode, you’ll discover the breakthrough science behind topical glutathione delivery that uses your skin’s water channels to raise intracellular glutathione levels in just 60 seconds. Learn how this powerful antioxidant works at the cellular level to reduce oxidative stress, support mitochondrial function, and drive real improvements in brain health, emotional resilience, and human performance.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Nayan Patel, a world-leading pharmacist and formulator who pioneered this next-gen delivery method. With over two decades of clinical work in functional medicine, Nayan has helped reshape how we think about glutathione benefits, systemic detox, and performance optimization. His research shows that topical delivery bypasses traditional fat-based absorption, achieving higher brain uptake and faster results than IVs or capsules.

You’ll learn:

• Why glutathione for longevity is foundational to biohacking

• How it protects against cellular inflammation and improves TBI recovery issues

• Why pairing glutathione with NAD+, vitamin C, or pharmaceutical nicotine creates a powerful synergy

• How it preserves NAD+, supports sirtuins, and enhances ATP production

• When to use glutathione as an immune booster for resilience and recovery

This conversation also reveals the truth behind liposomal supplements, how your age affects glutathione absorption, and why this molecule is critical for anyone using nootropics, in ketosis, or pushing metabolic limits.

This episode is essential listening for anyone into biohacking, cold therapy, functional medicine, or RFK-style medical freedom. You’ll walk away with practical tools to boost nitric oxide naturally, prevent dysfunction, and optimize your biology whether you’re on a carnivore diet or just looking for an edge.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Resources:

• Auro Wellness Website: Use code ‘dave10’ at checkout https://aurowellness.com/

• Dave Asprey’s Website: https://daveasprey.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

• 00:00 Trailer

• 00:20 Intro