Join Shalin Shah, CEO of Marius Pharmaceuticals and innovator behind Kyzatrex, an oral testosterone therapy that minimizes liver toxicity. He shares his journey from finance to health, illuminating how Kyzatrex's unique lymphatic absorption method offers safer alternatives for testosterone treatment. They tackle the side effects of traditional therapies, discuss patient education's role, and delve into the Testosterone Project's mission to improve access and understanding of hormone therapy. A groundbreaking conversation for anyone interested in the future of testosterone care.
Kyzatrex offers a groundbreaking oral testosterone therapy that mitigates liver toxicity risks through its innovative lymphatic absorption method for safer hormone management.
The podcast emphasizes the importance of public education on testosterone therapy's health benefits and risks, advocating for awareness and accessibility in treatment options.
Deep dives
Transformative Testosterone Replacement with Kaisotrex
Kaisotrex is an FDA-approved oral testosterone formulation that addresses the historical challenges of earlier oral versions, particularly the risk of liver toxicity. Utilizing a novel lymphatic absorption method, Kaisotrex presents a safer and more convenient solution to testosterone replacement therapy for both men and women. The innovative approach provides a means to maintain endogenous testosterone levels, thereby reducing the risks of side effects like testicular atrophy and infertility commonly associated with traditional testosterone treatments. This paradigm shift not only caters to a growing demand for safer therapies but also represents a significant advancement in hormone replacement strategies.
Health Risks Associated with Traditional Testosterone Treatments
Traditional testosterone replacement methods, such as injections and gels, can pose serious health risks, particularly regarding hematocrit levels. Standard high-dose testosterone injections have been linked to complications including erythrocytosis, which significantly increases the risk of cardiovascular events due to elevated red blood cell counts. In contrast, Kaisotrex has demonstrated a sub-2% rate of erythrocytosis in clinical trials, offering a much safer alternative to the risks associated with conventional high-dose injections. The discussions surrounding these risks underline the critical need for patient education about hormone therapies and their potential consequences.
The Importance of Free Testosterone Measurement
Understanding the difference between total testosterone and free testosterone is crucial for both patients and healthcare providers. Kaisotrex effectively lowers sex hormone-binding globulin (SHBG), resulting in a significant increase in free testosterone, which is the biologically active form that the body can utilize. With free testosterone levels doubling in clinical trials, patients can experience enhanced benefits, including improved energy, libido, and overall well-being without needing elevated total testosterone levels. This highlights the importance of focusing on free testosterone levels, as they are a more accurate indicator of the hormonal balance necessary for optimal health.
The Need for Educational Outreach on Testosterone Therapy
There is an urgent need for public education regarding testosterone therapy and its benefits, as many misconceptions still exist about hormone replacement. Initiatives like the Testosterone Project aim to promote regular testosterone testing in men over 40, raising awareness of the hormone's influence on metabolic health. Additionally, the project seeks to highlight the importance of testosterone for women's health, acknowledging that it plays a vital role in female physiology as well. Advocacy for de-scheduling testosterone as a controlled substance aims to increase accessibility to this crucial therapy, positioning it as a key element in improving metabolic health and overall well-being.
Discover the future of testosterone replacement therapy as we welcome Shalin Shah, the visionary CEO of Marius Pharmaceuticals, who has made the bold leap from an investment background to the forefront of medical innovation. Shalin shares his journey and unveils Kyzatrex, the FDA-approved oral testosterone that promises to change the game by sidestepping the liver toxicity risks associated with earlier oral options. With Kyzatrex’s novel lymphatic absorption method, we showcase why this advance is the answer to the pressing demand for safer and more convenient testosterone treatments for both men and women. Full disclosure: I use Kyzatrex with my patients who need testosterone at our Gatlan telemedicine practice.
Explore the intricate world of testosterone replacement therapy side effects, particularly how different treatments impact hematocrit levels. We tackle the significant health risks linked to high-dose testosterone injections, such as erythrocytosis and polycythemia, and how Kyzatrex may offer a safer alternative. Delve into the potential benefits like maintaining endogenous testosterone levels, which could minimize risks of testicular atrophy and infertility. This episode is a must-listen for those wanting to understand the delicate balance involved in hormone therapy and the critical importance of patient education to avoid unintended health consequences.
Lastly, immerse yourself in the transformative goals of the Testosterone Project, a nonprofit initiative championing routine testosterone testing for individuals over 40 and spotlighting testosterone's vital role in women's health. Shalin stands firm in his belief that the descheduling of testosterone could lead to better public health outcomes. This episode is packed with resources and insights into the evolving world of testosterone therapy, urging listeners to rethink conventional approaches and embrace innovative treatments. Join us in this critical conversation that promises to reshape how testosterone is perceived and utilized in healthcare.