Optimizing Ozempic, GLP-1 + Metabolic Wellness | Dr. Leonard Pastrana
Jul 24, 2024
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Former pharmacist Leonard Pastrana discusses optimizing Ozempic and GLP-1 treatments through exercise, diet balance, hydration, and supplements. Topics include insulin sensitivity, muscle health, longevity assessments, and utilizing GLP-1 for cardiovascular disease. Practical advice on holistic health approaches for metabolic wellness.
Optimizing Ozempic and GLP-1 involves a holistic approach integrating exercise and nutrition for enhanced insulin sensitivity.
Exercise plays a vital role in health optimization by activating metabolic processes and enhancing cellular pathways.
Maintaining muscle strength is crucial during GLP-1 treatments, emphasizing the importance of hydration and osmolites for muscle performance.
Deep dives
Optimizing Ozempic or GLP-1 Journey and Adjunctive Options
When focusing on optimizing the Ozempic or GLP-1 journey, it was emphasized that this treatment should be part of a comprehensive plan rather than a standalone therapy. Dr. Leonard Pastrana highlighted the importance of incorporating exercise, nutrition, and cellular optimization medicine for effective health span optimization. Patients were advised to go beyond pharmaceuticals and explore various adjunctive options to enhance the benefits of Ozempic, ensuring a holistic approach to treatment.
Importance of Exercise and Strength Training
Exercise and strength training were underscored as crucial components in health optimization, particularly in improving insulin sensitivity. Dr. Pastrana discussed the significance of AMPK activation through exercise, linking it to key metabolic processes like fatty acid oxidation and mitochondrial biogenesis. The conversation highlighted that exercise, similar to peptides, influences cellular pathways that enhance metabolism and energy production, emphasizing the essential role of physical activity in achieving overall well-being and cognitive function.
Maintaining Muscle Mass and Importance of Intracellular Water
The podcast delved into the nuances of maintaining muscle mass while using GLP-1 treatments, emphasizing the importance of muscle strength over mass for better health outcomes. It was suggested that hydration and intracellular water play a critical role in cellular health and muscle performance, notably impacting muscle strength gains and metabolic flexibility. The discussion extended to the use of amino acid osmolites and creatine to optimize cellular hydration, highlighting their potential to enhance performance, maintain muscle mass, and improve overall health.
Exploring the Use of Low Doses of Leucine in Cellular Medicine
Low doses of leucine have shown an interesting alternative function aside from its typical role in activating mTOR for protein synthesis. Studies have demonstrated that low doses of leucine can reduce the amount of NAD required to activate sirtuins, thus benefiting metabolic and exercise-related pathways. Combining low doses of leucine with other coactivating compounds has shown promising results in terms of fat oxidation, mitochondrial function improvement, and antioxidant enzyme upregulation.
Utilizing Citronol LNA as a Supplement in Cardiovascular Support
Citronol LNA, containing polymethoxylated flavones and tocotrienols, has demonstrated efficacy in reducing APoB, LDL, and triglyceride levels in human studies. The inclusion of nobelatin in citronol as a potent activator of CERT1 enhances its anti-inflammatory effects and lipid benefits. This supplement, coupled with low doses of leucine and nicotinic acid, offers a compelling combination for cardiovascular support, especially for patients at risk of cardiovascular disease.
EP. 162: How do you strike the perfect balance between traditional medication and holistic health approaches? Join me on today’s episode of the Dr. Tyna Show for an enlightening conversation with Dr. Leonard Pastrana, a former pharmacist who transitioned into cellular optimization. We uncover the secrets behind optimizing Ozempic and GLP-1 treatments, focusing on the holistic integration of exercise, nutrition, and comprehensive treatment plans to enhance insulin sensitivity and overall health. Dr. Pastrana sheds light on the biochemical mechanisms of these interventions and their profound impact on mitochondrial function, inflammation reduction, and metabolic health. This episode is jam-packed with practical advice and insights to help you optimize your health journey.
Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
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