EconTalk How to Be a Super Ager (with Eric Topol)
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Jun 23, 2025 
Eric Topol, a leading cardiologist at the Scripps Research Institute and author of "Super Agers," shares groundbreaking insights on aging and health. He debunks myths about genetics and highlights the role of the immune system in preventing diseases like Alzheimer’s and cancer. Topol discusses how a shingles vaccine could reduce dementia risk and the anti-inflammatory benefits of Ozempic. He also emphasizes the importance of deep sleep for brain health and the potential of innovative therapies to extend longevity.
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Immune system key to aging
- Chronic diseases like cancer, cardiovascular, and neurodegenerative conditions develop over decades, not months or years.
- Our genes contribute less than expected; immune system regulation is crucial for healthy aging.
GLP-1 drugs' surprising power
- GLP-1 drugs, like Ozempic, interact with gut hormones affecting brain and immune system function.
- These drugs unexpectedly reduce inflammation and addiction by gut-brain immune interactions.
Prioritize Deep, Regular Sleep
- Maintain a regular sleep schedule to reduce risks of dementia, cardiovascular disease, and cancer.
- Prioritize deep sleep early at night for brain detoxification and inflammation reduction.
