AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory
Oct 31, 2023
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The podcast discusses the effectiveness of longevity supplements like Resveratrol, NMN, and NR. It explores their impact on lifespan and energy levels. The role of Emtor in cellular growth and potential longevity effects is also explored. Factors for longevity and cognitive function like exercise, sleep, and nutrition are highlighted. The podcast also discusses the Huberman Lab Premium channel and its support for human research.
Resveratrol does not increase lifespan, but may have positive effects on cellular functioning.
NAD-related supplements show potential to increase lifespan, but their effects in humans are uncertain and NAD infusions are uncomfortable.
Deep dives
Resveratrol and Lifespan
Resveratrol supplements were once believed to have the potential to extend lifespan, but current thinking suggests that there is very little direct evidence to support this claim. While Resveratrol may have positive effects on cellular functioning, it does not seem to increase lifespan.
NAD and Longevity
NAD-related pathways, such as NR and NMN supplementation, have been explored as methods to increase NAD levels and potentially extend lifespan. While there is animal data suggesting a potential increase in lifespan, it is unclear whether these effects can be replicated in humans. NAD infusions have also been attempted to directly increase NAD levels, but their discomfort and limited evidence make them less desirable.
Metformin, Rapamycin, and Longevity
Metformin and rapamycin are commonly discussed as possible supplements for increasing longevity. However, the current data do not provide sufficient evidence to support their efficacy in extending lifespan. These supplements have potential side effects, and their benefits for longevity are still uncertain. It is important to prioritize sleep, exercise, nutrition, stress modulation, and social connection as foundational aspects for a long and healthy life.
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