Mitochondrial Health and Urolithin A with Dr. Anurag Singh | The Metabolic Link Ep. 41
May 21, 2024
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Dr. Anurag Singh, CMO of Timeline, discusses Urolithin A's impact on mitochondrial health, muscle strength, and inflammation. They explore mitophagy, synergistic effects with ketones, and transdermal delivery systems. Urolithin A's potential in combatting age-related decline and future applications is also highlighted.
Urolithin A enhances muscle strength through mitophagy and offers potential benefits in oxidative stress reduction.
Combining Urolithin A with other mitochondrial enhancers can optimize cellular energy production and improve overall health.
Deep dives
Introduction and Background of Dr. Anurag Singh
Dr. Dominic DeGestino introduces Dr. Anurag Singh, the Chief Medical Officer at Timeline Nutrition, highlighting his medical degree in internal medicine and a PhD in immunology. Dr. Singh's journey from medical school in India to the US, where he transitioned to full-time research due to limited research opportunities in India, sparked his interest in nutrition research. His exposure to nutrition research began while working closely with naturopaths on a compound from pineapple stems called bromelain, leading to his interest in nutrition.
Research Focus on Urolithin A
The key focus of the podcast centers around the science and potential applications of urolithin A (UA), a postbiotic compound that triggers the effects of mitophagy and enhances muscle strength. Dr. Singh sheds light on the molecular mechanism of UA-induced mitophagy, emphasizing its role in clearing out faulty mitochondria for the regeneration of healthy mitochondria. The conversation delves into the potential benefits of UA in various applications, from oxidative stress reduction to muscle health improvement.
Clinical Trials and Research Applications
Dr. Singh details the extensive clinical trials conducted on UA, with a special focus on applications in muscle strength improvement and oxidative stress reduction. The trials span various age groups, including middle-aged and older adults, highlighting the positive impact of UA on muscle function, exercise performance, and mitochondrial health. Discussions also touch upon future research directions, exploring the potential applications of UA in areas like inflammation, gut health, autoimmune conditions, and cancer-related muscle wasting.
Synergies and Future Prospects
Dr. Singh explores synergistic possibilities of combining UA with other mitochondrial enhancers like NAD boosters, coenzyme Q10, and creatine for amplified benefits in mitochondrial function and cellular energy production. Emphasizing the significance of maintaining a healthy lifestyle through proper diet, physical activity, stress management, and quality sleep, Dr. Singh underscores the holistic approach to enhancing mitochondrial health and overall well-being. The conversation concludes with a glimpse into ongoing and future research endeavors focused on exploring UA's potential synergies, application in rare diseases, and its promising implications in areas like brain aging, inflammation, autoimmunity, and immune metabolism.
Join us in this enlightening episode as we dive deep into the emerging research behind Urolithin A and its impact on mitochondrial health with Dr. Anurag Singh, a leading expert in the field and the Chief Medical Officer of Timeline.
The discussion spans various facets of Urolithin A, from its origin in pomegranates and other foods to its potential in improving mitochondrial health, muscle strength, and reducing inflammation. Dr. Singh shares insights from his decade-long research on this remarkable compound, discussing everything from the science of mitophagy to its implications for overall health. You’ll also hear about the synergistic effects of combining Urolithin A with other mitochondrial-targeting compounds and therapies like ketogenic diets and exogenous ketones.
The episode also reveals fascinating findings on how Urolithin A interacts with our cellular machinery to combat age-related decline and offers a peek into future applications, including a unique perspective on transdermal delivery systems. Dr. Singh’s expert knowledge sheds light on the exciting future directions of Urolithin A research and its vast potential applications.
About Dr. Anurag Singh: Dr. Anurag Singh is currently the Chief Medical Officer at Timeline, a company that develops next-generation advanced nutritional products targeting improvements in mitochondrial and muscle health. With an M.D. in internal medicine and a Ph.D. in immunology, his experience includes work for top consumer health and startup/biotech companies. He’s authored more than 40 articles in top science journals and has designed and led more than 50 randomized clinical trials in nutrition.
Special thanks to our sponsors of this episode: Genova Connect, powered by Genova Diagnostics offers easy access to advanced lab tests, covering key health areas like metabolic health, nutrition, gut health, immune function, and hormones. Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclink
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In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!
Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.
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