Emergency Medicine Cases Journal Jam 18 The Evidence for TXA – Should Tranexamic Acid Be Routine Therapy in the Bleeding Patient?
Jun 29, 2021
Dr. Ken Milne, an EBM guru, joins the hosts to examine the evidence for TXA in various indications including epistaxis, postpartum hemorrhage, hyphema, and hemoptysis. They discuss the limitations of the Cochrane review, the uncertain effectiveness of TXA in gastrointestinal bleeds, and the No-Pack trial results for epistaxis. The importance of replication in scientific studies and the pitfalls of subgroup analysis are also explored.
Chapters
Transcript
Episode notes
1 2 3 4 5 6 7 8 9
Introduction
00:00 • 2min
The Use of Tranexamic Acid in the Perioperative Period
01:51 • 3min
Limitations of Cochrane Review and Importance of Patient-Oriented Outcomes
05:00 • 2min
Tranexamic Acid (TXA) in GI Bleeds: Uncertain Effectiveness
07:30 • 21min
Results of the No-Pack Trial for Epistaxis and the Importance of Clinical Expertise
28:56 • 3min
Use of Tranexamic Acid (TXA) for Epistaxis
32:18 • 24min
The Importance of Replication in Scientific Studies
55:56 • 17min
The Pitfalls of Subgroup Analysis in Medical Trials
01:13:24 • 3min
Interpretation of Tranexamic Acid (TXA) in Clinical Trials
01:16:13 • 9min